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    A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage

    A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage by YuYa Wang, Wei Yang, YuanSong Yang, HuiHui Cheng, Rui Xiong, Xi Wu, Nan Xu, ShuNan Liu, Zhe Qu, Chen Ling, Yuan Cao, Yanwei Yang, HaoYang Zhao, WenDa Gu, Yong Wu, SuSu Liu, Yining Wang, Yu Wang, SanLong Wang, Rui Fu, WeiJin Huang, Hongning Zhou, Wei Wei, Jing An, YouChun Wang, ChangFa Fan

    Published 2025-12-01

    Dengue virus (DENV) infection remains a critical global health threat, with DENV-2 being the most virulent serotype capable of causing lethal dengue hemorrhagic fever (DHF), a severe complication characterized by plasma leakage and hemorrhagic manifestations. While the search for viral receptors and...

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