Search Results - Stefan Holdenrieder
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Comparison of methods for the isolation of cell-free DNA from cell culture supernatant
Published 2020-04-01Get full textIn vitro characterization of cell-free DNA using two-dimensional cell culture models is emerging as an important step toward an improved understanding of the physical and biological characteristics of cell-free DNA in human biology. However, precise measurement of the cell-free DNA in cell culture m...
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Comparison of methods for the quantification of cell-free DNA isolated from cell culture supernatant
Published 2019-08-01Get full textGaining a better understanding of the biological properties of cell-free DNA constitutes an important step in the development of clinically meaningful cell-free DNA–based tests. Since the in vivo characterization of cell-free DNA is complicated by the immense heterogeneity of blood samples, an incre...
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Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers
Published 2017-10-01Get full textEvidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays–based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate ant...
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Technical and clinical performance of a new assay to detect squamous cell carcinoma antigen levels for the differential diagnosis of cervical, lung, and head and neck cancer
Published 2018-04-01Get full textIn squamous cell carcinoma, squamous cell carcinoma antigen levels are often elevated. This multi-center study evaluated the technical performance of a new Elecsys ® squamous cell carcinoma assay, which measures serum squamous cell carcinoma antigen 1 and 2 levels in an equimolar manner, and investi...
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Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells
Published 2018-09-01Get full textThe true importance of cell-free DNA in human biology, together with the potential scale of its clinical utility, is tarnished by a lack of understanding of its composition and origin. In investigating the cell-free DNA present in the growth medium of cultured 143B cells, we previously demonstrated...
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Diagnostic relevance of a novel multiplex immunoassay panel in breast cancer
Published 2017-06-01Get full textMultiple factors contribute to the development and progression of breast cancer. Markers of tumor growth and invasion, cell death, immune activation, and angiogenesis can be assessed in parallel by a novel multiplex immunoassay panel. The diagnostic performance of a multiplex cancer biomarker magnet...
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Capillary Blood for Prostate-specific Antigen Testing: The PSA-CAP Study
Published 2025-08-01Get full textRisk-adapted prostate cancer (PC) screening is currently based on a combination of prostate-specific antigen (PSA) testing, risk assessment, and magnetic resonance imaging (MRI). Classical venous blood sampling is usually performed by health care professionals, which may reduce participation in futu...
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A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test
Published 2020-09-01Get full textThis study aimed to investigate whether changes in progastrin-releasing peptide (ProGRP) levels correlate with treatment response and can be used to optimize clinical management of patients with small-cell lung cancer. Patients with small-cell lung cancer (any stage) receiving chemotherapy were elig...
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