Search Results - Songbo Fu
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Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression
Published 2025-05-01Get full textAge-related macular degeneration (AMD), the leading cause of irreversible blindness worldwide, represents a complex neurodegenerative disorder whose pathogenesis remains elusive. At the core of AMD pathophysiology lies the retinal pigment epithelium (RPE), whose epithelial–mesenchymal transition (EM...
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Targeting CD4+ T Cell Glucose Metabolism: A Novel Immunotherapeutic Approach for Type 1 Diabetes
Published 2025-05-01Get full textType 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of insulin-producing β-cells. Emerging evidence highlights the pivotal role of CD4+ T cell subsets in driving T1D pathogenesis, where their activation, proliferation, and differentiation are tightly regulated by g...
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Long‐Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population‐Based Prospective Cohort and a Case–Control Study
Published 2025-06-01Get full textABSTRACT Background Antibiotics in childhood are commonly used and have been linked to gut microbiome dysbiosis and metabolic disorders. However, direct evidence regarding the association between long‐term or recurrent antibiotic use (LRAU) during early life and diabetes was scarce. We performed thi...
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