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    A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations

    A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations af Alfredo D. Smart, Merryn E. Hughes, Angela Downie Ruiz Velasco, Naoto Hori, Snow Stolnik, Catherine L. Jopling

    Udgivet 2025-09-01

    Messenger RNA (mRNA) therapeutics show considerable promise but face delivery challenges, as effective cytosolic entry and subsequent translation are normally limited by endosomal entrapment. While various approaches have been used to investigate determinants of effective RNA delivery, these methods...

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