Résultats de la recherche - Sing Lau
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The winter North Atlantic Oscillation downstream teleconnection: insights from large-ensemble climate model simulations
Publié 2025-01-01Accéder au texte intégralThe winter North Atlantic Oscillation (NAO) is the dominant pattern of atmospheric circulation variability over the North Atlantic region. It influences climate and weather such as surface air temperatures downstream over Eurasia through establishing a large-scale teleconnection, but past studies on...
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Disparities in health-related quality of life between patients with primary and secondary antibody deficiencies
Publié 2025-08-01Accéder au texte intégralBackground: The impact and burden of antibody deficiencies, especially secondary antibody deficiency (SAD), among adult patients remain largely understudied. Specifically, the health-related quality of life (HRQoL) of patients with SAD, compared to patients with primary antibody deficiency (PAD) rem...
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong
Publié 2025-02-01Accéder au texte intégralIntroduction COVID-19 infection is associated with post-acute adverse outcomes affecting multiple organ systems. Although preliminary studies have suggested that COVID-19 re-infection may have a cumulative effect on long-term outcome, differential effects of COVID-19 re-infection severe enough to be...
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Identification of technically challenging variants: Whole-genome sequencing improves diagnostic yield in patients with high clinical suspicion of rare diseases
Publié 2025-07-01Accéder au texte intégralSummary: The total burden of rare diseases is significant worldwide, with over 300 million people being affected. Many rare diseases have both well-defined clinical phenotypes and established genetic causes. However, a remarkable proportion of patients with high clinical suspicion of a rare disease...
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Informing trial measurement in systemic lupus erythematosus: frequency of domain-specific disease activity in a multinational cohort
Publié 2025-07-01Accéder au texte intégralObjective To report the prevalence of disease activity in individual SLE organ domains, including prevalence stratified by the most common disease activity cut-off score for clinical trial eligibility (SLE Disease Activity Index 2000; SLEDAI-2K ≥6).Methods We used data from a multinational longitudi...
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