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    Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques

    Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques av Rocio A. Barahona, Nellie E. Kwang, Aashna R. Kono-Soosaipillai, Giovanna Rubio Salgado, Kristine M. Tran, Yueh-Hao Lu, Siddharth Reddy, Celia da Cunha, Eric Velazquez-Rivera, Joshua D. Crapser, Xiangmin Xu, Lindsay A. Hohsfield, Kim N. Green

    Publicerad 2025-08-01

    Summary: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles. Recent evidence implicates extracellular matrix (ECM) dysfunction in disease pathogenesis, including extensive loss of perineuronal nets (PNNs). PNNs are neuron-ensheathing...

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