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    Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

    Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy by Linzhu Zhang, Di Wang, Yiming Liu, Nailin Yang, Shumin Sun, Chunjie Wang, Duo Wang, Jihu Nie, Juan Qin, Lei Zhang, Liang Cheng, Haidong Zhu

    Published 2025-11-01

    Pyroptosis is a critical process that triggers inflammatory responses and mitochondrial DNA (mtDNA) release, thereby activating the cGAS-STING pathway. However, tumor metabolism, particularly glycolysis, often suppresses immune activation. To address this, we developed GOCoF2, a self-amplifying pyro...

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