Search Results - Sheng-wang JIANG

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  1. 1
    Targeted myostatin loss-of-function mutation increases type II muscle fibers in Meishan pigs

    Targeted myostatin loss-of-function mutation increases type II muscle fibers in Meishan pigs by Li-li QIAN, Jing-yi XIE, Ting GAO, Chun-bo CAI, Sheng-wang JIANG, Han-fang BI, Shan-shan XIE, Wen-tao CUI

    Published 2022-01-01

    Myostatin (MSTN) is a negative regulator of skeletal muscle growth and development. The skeletal muscle in MSTN−/– mice is significantly hypertrophied, with muscle fiber type II increasing significantly while muscle fiber type I decreasing. However, it is still not clear how the skeletal muscle type...

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  2. 2
    Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

    Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site by Li-li QIAN, De-zun MA, Peng-fei GAO, Sheng-wang JIANG, Qing-qing WANG, Chun-bo CAI, Gao-jun XIAO, Xiao-rong AN, Wen-tao CUI

    Published 2016-11-01

    Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development. In this study, we generated transgenic mice that express porcine myostatin containg mutations at its cleavage site (RSRR) to evaluate its...

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