Search Results - Shasha Shi

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    Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion

    Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion by Mien-Chie Hung, Jun Yao, Chia-Hung Chen, Chih-Yen Tu, Zhiguo Liu, Qihui Chen, Liyan Gu, Dongli Linghu, Jiaming Song, Chengjie Liu, Boning Liu, Riyao Yang, Swathi Priya Manickam, Navaneethan Sundhar, Delong Liu, Hsiao-Fan Chen, Shasha Shi, Shunjie Xiong, Linlin Sun

    Published 2025-07-01

    Background Despite the remarkable clinical outcomes of epidermal growth factor receptor (EGFR)-targeted therapies in patients with lung cancer, therapeutic resistance eventually develops. This study elucidates the role of galectin-9 (Gal-9), a TIM-3 immune checkpoint ligand, in facilitating tumor im...

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