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    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways by Yongkang Liu, Xing Kang, Geng Niu, Senlin He, Tingting Zhang, Yuwei Bai, Yi Li, Houyan Hao, Chao Chen, Zhexing Shou, Bin Li

    Published 2019-12-01

    Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy in A375 cells and i...

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