Search Results - S. V. Nedogoda

In this literature review indicates the importance of monitoring the heart rate in the selection and prescription of adequate antihypertensive therapy.

This paper compares the results of multiple studies on antihypertensive diureticsand various clinical parameters in patients with arterial hypertension, includingvascular stiffness, end-points, hypotensive effects, organ protection, potassiumlevels, and metabolic effects.

The ADVANCE Study, started in early 2001, included 11140 patients aged over 55 years, with Type 2 diabetes mellitus (DM-2) and one more risk factor (RF): age 65 years and above, macro- or microvascular pathology in anamnesis, DM-2 duration over 10 years, etc. In patients with DM-2 and arterial hyper...

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The data from a range of large trials (LEADER, EMPA-REG, CANVAS) show evidently the practical use of the modern glucose lowering drugs usage for successful management of cardiovascular risk in type 2 diabetes (DM2) patients. The article is focused on analysis and review of possible mechanisms and be...

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The features of various statins’ use are analysed taking into consideration their clinical and pharmacological parameters. The present evidence base on atorvastatin and rosuvastatin is emphasised. The author compares various statins in regard to their potential in atherosclerotic plaque reduction, a...

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The article focuses on the "pros" and "contras" of thiazide containing combinations usage for treatment of arterial hypertension in real clinical practice. Based on evidence, clear indications are formulated for effective and safe application of the ramipril and hyndrochlorothiaz...

Results of randomized clinical trials on the usage of calcium antagonists (CA) in order to prevent perioperative complications during aortocoronary bypass procedure and operations on heart valves are analyzed. CA reduced the risk of perioperative myocardial infarctions and episodes of reversible myo...

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Peculiarities of the treatment with angiotensin II receptor blocker telmisartan are analyzed taking into account its clinical and pharmacological characteristics. Special attention is paid to the telmisartan benefits in comparison with other sartans. Key details of telmisartan interaction with perox...

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The article provides the large prospective researches data which testify the more important role of systolic blood pressure increase in arterial hypertension forecast. Here comes the conclusion that the most perspective drugs for systolic blood pressure reduction today are diuretics. Indapamid SR (A...

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HYVET Study was aimed at assessing the effects of indapamide SR (1,5 mg/d), as monotherapy or combined with an ACE inhibitor perindopril (2-4 mg/d), compared to placebo, on the risk of stroke and other cardiovascular events in arterial hypertension patients aged over 80 years. Active indapamide SR t...

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The number of patients with metabolic syndrome and obesity is continuously increasing. Specifics of arterial hypertension in obesity is related to activation of renin-angiotensin-aldosterone system and sympathetic system, inflammation, early and prominent target organs damage, which is significant t...

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A review of the efficacy and safety of diuretics in hypertension was carried out from the standpoint of current clinical guidelines. Also, updated data from metaanalyzes of the efficacy and metabolic effects of diuretic therapy were reviewed. Currently, a more differentiated approach to the appointm...

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The review contains original data and international studies’ results demonstrating that selective I1 imidazoline receptor agonists, and, in particular, Albarel®, a new sympatholytic agent, provide not only adequate and longterm blood pressure control, but also other beneficial metabolic and vascular...

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Aim. To evaluate the features of pharmacotherapy in achieving different levels of target blood pressure (BP) in patients with arterial hypertension (AH) with the absence or presence of comorbid diseases in real outpatient practice.Material and methods. At the open multicenter observational study, ou...

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Aim. To assess and compare 6-month monotherapy effectiveness for losartan and lisinopril, according to their effects on blood pressure (BP), vascular elasticity, and cognitive function in patients with Stage I-II arterial hypertension (AH). Material and methods. This open clinical trial included 15...

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Aim. To study the opinion of primary care physicians and hypertensive (HTN) outpatients with different compliance rate on factors preventing effective antihypertensive therapy (AHT).Material and methods. Primary care physicians and HTN outpatients were questioned. Questionnaires for physicians and p...

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Objective: to assess the economic outcomes of using anidulafungin (Eraxis®) in comparison with the recommended treatment regimens in adult patients with invasive candidiasis.Materials and methods. The economic impact assessment was carried out using “cost–effectiveness” analysis and “budget impact”...

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