Search Results - S. A. Shalnova

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Approaches to the evaluation of drug efficacy and safety are discussed. The specifics of clinical and observational trails are presented. The trail data on statins efficacy and safety are held up as a model.

The article discusses a new approach to assessing cardiovascular risk in clinical practice, presented in the European guidelines 2021. Two novel risk charts (SCORE2 and SCORE2-OP) have been proposed that have undergone significant revision and require significant changes in primary care practice. It...

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Высокая сердечно-сосудистая смертность, составляющая более половины смертности от всех причин в России, перестала быть предметом интереса узкого круга специалистов и приобрела общегосударственное значение. Возрастающее бремя неинфекционных болезней, в значительной степени обусловленное сердечно-сосу...

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The organization of randomized clinical trials (RCTs) in accordance to the principles of Good Clinical Practice (GCP) is presented. The situation with RCTs in Russia and worldwide is also considered. Issues that must be addressed to improve a quality of the RCTs are reviewed. Information about Russi...

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Aim. To compare trends from CVD and cancer mortality in the Russian Federation from 2000 to 2016. depending on age and gender.Material and methods. The official statistics on mortality of Federal state statistics Service and the data obtained in the Russian database of fertility and mortality of the...

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Cardiovascular diseases (CVD) play leading roles among the main causes of death around the globe. In 2009 the American Heart Association developed the Model of Cardiovascular Health (CVHealth) and implemented the meaning of an "ideal", "average" and "poor" CVHealth. In...

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Aim. To present the results of OSCAR‑2006 therapeutic program; to discuss lipid‑lowering therapy effectiveness in real‑world clinical practice. Material and methods. In total, the study included 7098 patients, with more than 50% suffering from verified (86,8%) coronary heart disease (CHD). The progr...

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Aim. To study trends in the prevalence of hypertension (HTN), obesity, elevated non-high-density lipoprotein cholesterol (non-HDL cholesterol) levels in Russia and the USA from 1975 to 2014.Material and methods. According to the data of cross-sectional population studies in Russia and the USA in 197...

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The article discusses the role of epidemiological studies in the development of preventive programs through the example of the ESSE-RF study. The most interesting and sometimes unexpected research results are discussed. There is an increase in the prevalence of hypertension and obesity, a decrease i...

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Assessment of cumulative risk of cardio-vascular diseases.

Aim. То assess the use of average therapeutic doses of atorvastatin and simvastatin (Torvacard and Simvacard) in real-world clinical management of high-risk patients.Material and methods. The study included 347 doctors from 30 Russian cities and 1163 high-risk patients randomised into two groups: To...

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The authors present literature review on the important clinical issue – arterial hypertension (AH) management in patients with Type 2 diabetes mellitus (DM-2). In DM-2 individuals, AH prevalence triples, and dangerous combination of AH and DM-2 substantially increases target organ damage (TOD) risk....

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From the second half of the XX century, cardiovascular disease (CVD) remains one of the main problems of the modern medicine. Over the last two decades, developed countries demonstrated a marked decrease in all-cause mortality and CVD mortality, in particular. InRussia, since the mid-1960s, all-caus...

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Aim. Program OSCAR-2006 has been initiated with an aim to identify high-risk patients in real-world clinical practice settings. The article presents the results from the epidemiological part of the Program. Material and methods. OSCAR-2006 Study included 235 doctors from 36 Russian cities, and 7098...

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At the moment, obesity is a global problem, with an increasing prevalence worldwide, which could be characterized as an obesity "epidemic". The article presents the distribution of body mass index (BMI) and abdominal obesity by age and gender in a representative national sample of the Russ...

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Aim. To present the results of the GARANT study, Part II, supported by the Society of Cardiology of the Russian Federation. To study the effects of fixed-dose enalapril and hydrochlorothiazide combinations on arterial hypertension (AH) treatment in real(world clinical practice. Material and methods....

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The review collects the data on the approaches to modeling of population risk of cardiovascular diseases (CVD), including methodological aspects and practical significance of modeling results. The general scheme is provided for population modeling that includes three steps: collection of data for in...

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Principles and fundamentals of proper presentation of observational epidemiological study results are focused. Principles of observational study publication developed by expert epidemiologists (STROBE statement) are explained in detail.

Aim. In the Russian national representative sample, to investigate gender-specific associations between educational level and body mass parameters: body mass index (BMI), waist circumference (WC), abdominal obesity (AO), as well as the links between education and cardio-metabolic risk (CMR) componen...

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