Search Results - S O Salugina

Tsel' issledovaniya. Otsenit' pokazateli kachestva zhizni (KZh) u detey i podrostkov, stradayushchikh razlichnymi formami yuvenil'-nogo artrita (YuA), cherez 10 let i bolee posle debyuta zabolevaniya. Materialy i metody. V issledovanie vklyucheny 94 patsienta s YuA v vozraste 11-18 le...

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Autoinflammatory diseases (AIDs) are a heterogeneous group of rare genetically determined conditions, the main manifestations of which are episodes of fever in combination with other signs of systemic inflammation: skin rashes, musculoskeletal and neurological disorders, damage to the organs of visi...

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The review is devoted to the most common monogenic autoinflammatory disease – familial Mediterranean fever (FML) caused by MEFV gene mutation that occurs mainly in the representatives of certain ethnic groups and manifests itself as recurrent 6–72-hour attacks of pyretic fever accompanied by the phe...

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Objective. To study outcome and prognosis in pts with juvenile idiopathic arthritis (JIA). Material and methods. 239 JIA pts with disease duration of 10 years and more were analyzed. 80 children and adolescents before 18 years old (66 girls and 14 boys) were included in group 1. Arthritis clinical a...

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Objective. To assess sandimmun neoral (SN) efficacy and safety in pts with juvenile chronic arthritis (JCA). Material and methods. 25 pts (20 girls, 5 boys) aged 3 to 15,5 years (mean 9,7±3,7 years) with JCA were included. 12 from them had systemic and 13 - joint form of the disease. 92% of pts had...

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Objective: to assess the frequency of prescription, efficacy and tolerability of biological disease-modifying antirheumatic drugs (bDMARDs) therapy in patients with major monogenic autoinflammatory diseases (mAID) according to the Federal Rheumatology Center clinical practice. Patients and methods....

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Objective: to test the hypothesis of a possible relationship between the rs12218 polymorphism of the SAA1 gene and a predisposition to different clinical phenotypes of juvenile idiopathic arthritis (JIA).Patients and methods. Genetic typing of rs12218 polymorphism was carried out in 142 children: 77...

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Objective. 7 cases of AHA syndrome (arthralgia, arthritis, hives, angioneuroticedema) in children described. Literature and own data are presented. Possible pathogenetic mechanisms, clinical symptoms and treatment are discussed.

Хронические артриты у детей являются важной проблемой современной педиатрии в силу того, что эти тяжелые заболевания существенно нарушают качество жизни ребенка и его родителей, требуют немалых экономических затрат на лечение и нередко приводят к инвалидности ребёнка. Этиология этих заболеваний в на...

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The paper gives the experience of the V.A. Nasonova Research Institute of Rheumatology in identifying and managing patients with familial Mediterranean fever (FMF). Objective: to describe the features of the disease in patients with FMF in Russia and to compare them with the data obtained in the stu...

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Objective: to present the experience of diagnosis, management and therapy with interleukin-1 inhibitors (iIL1) in patients with Chronic Infantile Onset Neurologic Cutaneous Articular/Neonatal Onset Multisystem Inflammatory Disease (CINCA/NOMID) according to the Russian Federal Rheumatological Center...

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The article presents information on the current state of the problem of autoinflammatory diseases (AID) in rheumatology, reflects the clinical and demographic, laboratory and molecular genetic characteristics of the main monogenic AID (mAID), the most common in real clinical practice. Approaches to...

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Gastrointestinal (GI) manifestations, such as abdominal pain, nausea, vomiting, and diarrhea, are common autoinflammatory disease (AID) symptoms. The abdominal symptomatology reflecting serositis is one of the most important classification and diagnostic criteria for the classic monogenic AID (MAID)...

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The article presents the development of the doctrine of autoinflammatory diseases (AID) in the last decade. Data on interleukin 1, inflammasomes and their role in the development of AID are presented. The paper also contains the data about interferonopathies and, in particular, proteasomal illnesses...

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Tumor necrosis factor (TNF) receptor-1-associated periodic syndrome (TRAPS) is a classical autoinflammatory syndrome (AIS). The paper describes repeated cases of TRAPS in an ethnic Russian family. Molecular genetic examination of a 9-year-old boy, his mother and his grandmother has revealed the hete...

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Cryopyrin-associated periodic syndromes (CAPS) are the most prominent representatives of monogenic autoinflammatory diseases (AIDs). They are characterized by a concurrence of fever, rash, and other symptoms that are accompanied by disabling or life-threatening complications. Based on the current gu...

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The mechanisms of action of currently used genetic engineering biological agents (GEBAs) include inhibition of cytokines, interleukins, and T cells and depletion of B cells. GEBAs were originally accessible mainly for the treatment of refractory juvenile idiopathic arthritis (JIA), including systemi...

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