תוצאות חיפוש - Søren Brunak

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  1. 1
    Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy

    Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy מאת Alexander Pil Henriksen, Cristina Leal Rodríguez, Hannah Currant, Ioannis Louloudis, Jorge Hernansanz Biel, Maria Herrero-Zazo, Ewan Birney, Thomas Folkmann Hansen, Gianluca Mazzoni, Amalie Dahl Haue, Henning Bundgaard, Christian Erikstrup, Khoa Manh Dinh, Liam Quinn, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Ole Birger Vestager Pedersen, Henrik Ullum, Sisse Rye Ostrowski, Karina Banasik, Søren Brunak

    יצא לאור 2025-01-01

    As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. Polypharmacy is known to complicate therapy and increase the risk of drug-drug interactions, the individuality of which remain largely unexplored. Here, we perform...

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  2. 2
    Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

    Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. מאת Lasse Folkersen, Eric Fauman, Maria Sabater-Lleal, Rona J Strawbridge, Mattias Frånberg, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E Humphries, Rainer Rauramaa, Ulf de Faire, Andries J Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Stefan Enroth, Åsa Johansson, Sofia Bosdotter Enroth, Stefan Gustafsson, Lars Lind, Cecilia Lindgren, Andrew P Morris, Vilmantas Giedraitis, Angela Silveira, Anders Franco-Cereceda, Elena Tremoli, IMPROVE study group, Ulf Gyllensten, Erik Ingelsson, Søren Brunak, Per Eriksson, Daniel Ziemek, Anders Hamsten, Anders Mälarstig

    יצא לאור 2017-04-01

    Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasm...

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  3. 3
    Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.

    Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study. מאת Richard Howey, Jonathan Adam, Jerzy Adamski, Natalie N Atabaki, Søren Brunak, Piotr Jaroslaw Chmura, Federico De Masi, Emmanouil T Dermitzakis, Juan J Fernandez-Tajes, Ian M Forgie, Paul W Franks, Giuseppe N Giordano, Mark Haid, Torben Hansen, Tue H Hansen, Peter P Harms, Andrew T Hattersley, Mun-Gwan Hong, Ulrik Plesner Jacobsen, Angus G Jones, Robert W Koivula, Tarja Kokkola, Anubha Mahajan, Andrea Mari, Mark I McCarthy, Timothy J McDonald, Petra B Musholt, Imre Pavo, Ewan R Pearson, Oluf Pedersen, Hartmut Ruetten, Femke Rutters, Jochen M Schwenk, Sapna Sharma, Leen M 't Hart, Henrik Vestergaard, Mark Walker, IMI DIRECT Consortium, Ana Viñuela, Heather J Cordell

    יצא לאור 2025-07-01

    Here we report the results from exploratory analysis using a Bayesian network approach of data originally derived from a large North European study of type 2 diabetes (T2D) conducted by the IMI DIRECT consortium. 3029 individuals (795 with T2D and 2234 without) within 7 different study centres provi...

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