Search Results - S, Parikh

This systematic review examines the evolving role of product manager (PM), from its inception in the early 20th century to its current state, with a focus on how technological advancements, shifting market dynamics, and evolving company’s strategy have shaped the profession. While numerous studies h...

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Background: Non-transfusion-dependent thalassemia (NTDT) patients can be at risk of iron overload, despite not being transfused frequently. Iron overload is a major risk factor that increases morbidity and mortality in non-transfusion dependent thalassemia patients. Aim: This study looked at the pre...

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Inhaled treprostinil is approved for the treatment of pulmonary hypertension-associated interstitial lung disease (PH-ILD); however, it has not shown significant benefit in patients with a pulmonary vascular resistance (PVR) < 4 WU. As such, treatment for non-severe PH-ILD remains controversial....

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# Background Studies have shown that improvements in glycemic control are associated with avoidance or delayed onset of diabetes complications, improvements in health-related quality of life, and reductions in diabetes-related health care costs. Clinical practice guidelines recommend maintaining a h...

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Ultrasound (US)-guided popliteal sciatic nerve block (PSNB) with a femoral nerve block (FNB) provides adequate surgical analgesia for below-knee (BK) debridements and amputations. This retrospective review of 16 American Society of Anesthesiologists physical status III and IV patients describes a US...

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Traumatic rupture of an extraocular muscle is noted infrequently. The medial and inferior rectus muscles are usually found to be affected. We report an unusual case of superior oblique and medial rectus rupture after a penetrating trauma by the metallic hook. The surgical repair was combined with bo...

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KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allostery remain poorly understood. In this study, we em...

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In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined all-atom molecular dynamics (...

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<h4>Background and aims</h4>Hepatorenal syndrome is a severe complication of cirrhosis and associates with significant mortality. Vasoconstrictor medications improve renal function in patients with hepatorenal syndrome. However, it is unclear to what extent changes in serum creatinine du...

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Background: Cerebrospinal fluid (CSF) leaks are a serious complication of endoscopic trans-sphenoidal surgeries that can lead to meningitis, pneumocephalus and a risk to life. Neurosurgeons have used perioperative lumbar drains to facilitate the healing of the dura and prevent postoperative CSF leak...

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<b>Background:</b> Gravity profoundly influences human locomotion. Studies examining the effects of hyper-gravity on gait have largely relied on added external mass, potentially confounding results with changes in inertia and center of mass. This study attempted to isolate the effects of...

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<h4>Objectives</h4>To perform a systematic review of randomized controlled trials to determine whether prevention or slowing of progression of chronic kidney disease would translate into improved mortality, and if so, the attributable risk due to CKD itself on mortality.<h4>Backgro...

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Liam Molina,1 Nora Lyang,2 Rachel Schwartz,1,3 Neeti Parikh,1,4 Saras Ramanathan,1,4 Alison J Huang,1,5,6 Catherine L Chen1,3,7 1School of Medicine, University of California San Francisco, San Francisco, CA, USA; 2Western University of Health Sciences, Pomona, CA, USA; 3Department of Anesthesia &...

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Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) and concomitant interstitial lung disease (ILD) are particularly challenging to manage due to concerns about ventilation–perfusion mismatch with systemic vasodilators. In this case series, we evaluated the e...

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Introduction. Hematopoietic stem cell transplant is an established management in various blood disorders. This contemporary management has improved patient survival; tackling immunosuppression and managing post-transplant complications is of prime importance. Post-transplant Diabetes Mellitus is one...

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