Search Results - Ruiping Du

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    Discovery of Synergistic Broadly Neutralizing Antibodies Targeting Non-Dominant Epitopes on SARS-CoV-2 RBD and NTD

    Discovery of Synergistic Broadly Neutralizing Antibodies Targeting Non-Dominant Epitopes on SARS-CoV-2 RBD and NTD by Hualong Feng, Zuowei Wang, Ling Li, Yunjian Li, Maosheng Lu, Xixian Chen, Lin Hu, Yi Sun, Ruiping Du, Rongrong Qin, Xuanyi Chen, Liwei Jiang, Teng Zuo

    Published 2025-05-01

    <b>Background/Objectives</b>: Identification and characterization of broadly neutralizing monoclonal antibodies from individuals exposed to SARS-CoV-2, either by infection or vaccination, can inform the development of next-generation vaccines and antibody therapeutics with pan-SARS-CoV-2...

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  2. 2
    A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

    A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls by Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang, Yunjian Li, Yi Sun, Rongrong Qin, Hualong Feng, Lin Hu, Xuanyi Chen, Maosheng Lu, Xueyan Huang, Haibo Wang, Liwei Jiang, Teng Zuo

    Published 2025-07-01

    Summary: The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after rec...

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