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    PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

    PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype by Shunlei Duan, Guohong Yuan, Xiaomeng Liu, Ruotong Ren, Jingyi Li, Weizhou Zhang, Jun Wu, Xiuling Xu, Lina Fu, Ying Li, Jiping Yang, Weiqi Zhang, Ruijun Bai, Fei Yi, Keiichiro Suzuki, Hua Gao, Concepcion Rodriguez Esteban, Chuanbao Zhang, Juan Carlos Izpisua Belmonte, Zhiguo Chen, Xiaomin Wang, Tao Jiang, Jing Qu, Fuchou Tang, Guang-Hui Liu

    Published 2015-12-01

    Abstract PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display neoplasm-associated metabolic and gene exp...

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