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Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. por Chaitali Misra, Nita Sachan, Caryn Rothrock McNally, Sara N Koenig, Haley A Nichols, Anuradha Guggilam, Pamela A Lucchesi, William T Pu, Deepak Srivastava, Vidu Garg
Publicado 2012-01-01Defects of atrial and ventricular septation are the most frequent form of congenital heart disease, accounting for almost 50% of all cases. We previously reported that a heterozygous G296S missense mutation of GATA4 caused atrial and ventricular septal defects and pulmonary valve stenosis in humans....
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