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    Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors

    Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors by Xinjiang Wang, Rati Lama, Alexis D. Kelleher, Erika C. Rizzo, Samuel L. Galster, Chao Xue, Yali Zhang, Jianmin Wang, Jun Qu, Sherry R. Chemler

    Published 2025-06-01

    Small molecule inhibitors that target the E3 ligase activity of MDM2-MDM4 have been explored to inhibit the oncogenic activity of MDM2-MDM4 complex. MMRi62 is a small molecule that was identified using an MDM2-MDM4 E3 ligase-based high throughput screen and a cell-death-based secondary screen. Our p...

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