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    SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury

    SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury av Hui Chen, Xiaoping Lin, Xiaohong Yi, Xiaofeng Liu, Ranghui Yu, Wenhao Fan, Yaping Ling, Yanan Liu, Weidang Xie

    Publicerad 2022-12-01

    Objective Acute lung injury (ALI) is a common complication of heat stroke (HS) and a direct cause of death. However, the mechanism underlying ALI following HS remains unclear.Method To investigate whether ferroptosis is involved in HS-ALI. We established a HS model of mice and mouse lung epithelial-...

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