Search Results - Randolph M. Lopez

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    AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity

    AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity by Aditya A. Agarwal, James Harrang, David Noble, Kerry L. McGowan, Adrian W. Lange, Emily Engelhart, Miranda C. Lahman, Jeffrey Adamo, Xin Yu, Oliver Serang, Kyle J. Minch, Kimberly Y. Wellman, David A. Younger, Randolph M. Lopez, Ryan O. Emerson

    Published 2025-12-01

    Antibodies are versatile therapeutic molecules that use combinatorial sequence diversity to cover a vast fitness landscape. Designing optimal antibody sequences, however, remains a major challenge. Recent advances in deep learning provide opportunities to address this challenge by learning sequence–...

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