Search Results - R. V. Denisova

The article contains results of therapeutic efficacy of ibuprofen in pain syndrome management in children. Validity of its use is doubtless. Analgesic effect of Ibuprofen has been confirmed in clinical trials in patients with migraine and ENT-disorders. In this article we also review international e...

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The article describes international multicenter controlled studies of efficacy and safety of monoclonal antibodies towards interleukin 1β — kanakinumab — when treating cryopyrin-associated periodic syndrome and systemic juvenile idiopathic arthritis in children. The results of the studies show that...

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The article represents the results of efficacy and safety evaluation of the human monoclonal antibodies — golimumab, according to the data of international multicenter randomized double-blind placebo-controlled trials, including patients with active stage of rheumatoid arthritis. It was shown, that...

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This article contains an example of a successful clinical use of human monoclonal antibodies to tumor necrosis factor (TNF) — adalimumab in patients with severe juvenile idiopathic spondylitis, characterized by resistance to standard antirheumatic treatment and secondary resistance to recombinant (c...

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The article contains analysis of international practice of abatacept use in treatment of refractory uveitis in patients with idiopathic juvenile rheumatoid arthritis. Efficacy of T-cell co-stimulation blockade in treatment of severe autoimmune fontal uveitis has been proven on the models. Described...

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Haemolytic anemia occurs in 10% of the cases of systemic lupus erythematosus in children with hematological disturbances. High doses of glucocorticoids are used for the treatment of this condition. The second-line drugs in cases of refractory disease course are azathioprine, mycophenolate mofetil, c...

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The article presents a case of successful use of therapeutic monoclonal antibodies to interleukin 1 (canakinumab) at severe systemic juvenile idiopathic arthritis. Canakinumab treatment promptly provided reduction in clinical and laboratory disease activity indicators, increase in life quality, deve...

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The article represents a history case of successful usage of tolicizumab (anti-interleukin 6 monoclonal antibodies) in treatment of severe systemic juvenile idiopathic arthritis, resistant to previous standard antirheumatic therapy. Tocilizumab treatment led to distal joints function restoration and...

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Modern successful treatment of rheumatic diseases is impossible without the use of intravenous immunoglobulin. The use of intravenous immunoglobulin is based on strict indications developed as a result of long-term multicenter controlled studies. The article highlights the issues of using immunoglob...

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The article presents the literature review of recent publications on efficacy and safety of methotrexate in treatment of juvenile rheumatoid arthritis. Administration of methotrexate 15 mg/m2 of body surface weekly results in significant decrease of inflammatory activity of rheumatoid process and in...

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The article presents a review of literature data, dedicated to problems of secondary ineffectiveness of infliximab in patients with rheumatoid arthritis. An analysis of available data showed that the main reason of resistance to the TNF α inhibitors is a synthesis of antibodies to the drug. Risk fac...

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The article presents a case of successful application of a monoclonal antibodies drug to interleukin 6 receptors (tocilizumab) at severe systemic juvenile idiopathic arthritis with the development of secondary hemophagocytic syndrome. Tocilizumab treatment secured a decrease in clinical and laborato...

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This review is dedicated to treatment of rheumatoid diseases in adults and children with one of TNF blockers adalimumab. The data from single, open9labeled, and multicenter double blinded placebo controlled studies of effectiveness and safety of adalimumab is presented. Analysis of many published in...

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Study objective — to evaluate etarnecept influence on quality of life of idiopathic juvenile arthritis patients’ quality of life. 25 patients with poly- and oligoarthritides aged 8 (6; 11) years. Before etarnecept use quality of life of all patients was significantly lower that that of healthy child...

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The theme of review is the results of treatment of rheumatic diseases in adults and children with blocker of TNF-α etanercept. The data from single, open-labeled and multicenter double blinded placebo-controlled studies of activity and safety of etanercept is presented in this article. The results o...

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The article presents mechanism of action of abatacept, literature data on clinical studies of its effectiveness in adults with rheumatoid arthritis, and results of clinical randomized double-blinded placebo-controlled study of abatacept effectiveness in treatment of different types of juvenile idiop...

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The article presents a case of successful use of a preparation of monoclonal antibodies to interleukin 6 receptors (tocilizumab) at asevere systemic juvenile idiopathic arthritis. Tocilizumab treatment promptly provided decrease of clinical and laboratory parametersof the disease activity, increase...

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The article presents a case report of a severe clinical course of systemic type of juvenile arthritis, resistant to treatment with corticosteroids and classic immunosuppressive agents in girl 9 years old. Biological agent — tocilizumab showed beneficial effect: exudative lesions of joints, morning j...

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Questions of differential diagnosis in conditions of developed systemic inflammatory reaction in patients with systemic type of juvenile rheumatoid arthritis (JRA) are one of difficult problems in children's rheumatology. Clinical signs, similar to sepsis, accompanied by development of symptoms...

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The article observes the data on the role of interleukin (IL) 6 in pathogenesis of rheumatoid arthritis and treatment of rheumatoid arthritis and different types of juvenile arthritis with blocker IL 6 receptor (tocilizumab). The data on multicenter open-labeled and double-blinded randomized studies...

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