Search Results - R. N. Shepel

Efficacy of omega-3 fatty acids in cardiology is so high that in many countries omega-3 fatty acids are included into the treatment protocols for patients with cardiovascular diseases. This therapeutic class slows down oxidative stress and chronic inflammation processes, thereby providing a signific...

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Telomeres and telomerase complex have got be known by scientists not long ago. At the current moment there quite large data on this topic collected. The row of diseases has been described that are caused by "shelterin" genes mutations, genes of telomerase complex subunits genes associated...

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Disorder of formation of vitamin B12, which has a wide range  of biological properties and is involved in the regulation of many important physiological functions, is the basis of a number of serious diseases. Usually internists consider that vitamin В12 deficiency is associated with disturbances of...

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Besides hypolipidemic effect statins demonstrate some not-lipid (pleotropic) ones. Special attention has been paying to statin inducing reduction in bacterial infections incidence and severity, and pneumonia particularly. Results of the large studies on statin influence on infectious disease are pre...

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Today the role of disturbances in sleep duration in the development of various chronic diseases, including cardiovascular diseases is known and proven. In addition, the results of many clinical studies demonstrate the relationship between impaired sleep duration and the rate of telomere shortening....

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Currently, there is rather contradictory evidence on the effectiveness of a low sodium diet for the prevention of various diseases. At that, it is a generally accepted fact, that it is necessary to reduce salt intake in order to reduce high blood pressure. An internist should remember that the degre...

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Chronic heart failure (CHF) is considered the leading cause of death in patients with established cardiovascular (CVD) and metabolic diseases. Although the current treatment strategy has improved survival and clinical outcomes, the prevalence of CHF shows an increase. Current clinical guidelines for...

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Aim. To assess the relationship between the levels of angiogenesis markers and various heart failure (HF) phenotypes in patients with class II-IV HF of ischemic origin.Material and methods. This cross-sectional cohort study was based on the clinical departments of the National Medical Research Cente...

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Review of clinical studies showing the pleiotropic effect of vitamin D with a detailed description of pathogenetic ways to implement these effects  is presented. Relation of vitamin D with cardiovascular diseases, kidney diseases, disorders of the immune and nervous systems, aging is discussed accor...

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The article presents the results of Russian and international clinical studies on the levels of angiogenesis markers (vascular endothelial growth factor, pentraxin 3 and transforming growth factor beta) in patients with metabolic syndrome.

The development  and progression of atherosclerosis in most cases takes decades, and at early stages does not present clinically. Multiple studies results witness that telomere   length  reflects  total  grade   of  DNA damage by  the  factors  that  are responsible for atherosclerosis and its compl...

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Aim. To study serum level of leptin in patients with the metabolic syndrome (MS), including in patients with MS in combination with left ventricular hypertrophy (LVH) to determine the diagnostic significance of this marker in MS.Material and methods. The study involved 43 patients with MS, 33 of the...

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The current stage of Russian healthcare development is characterized by the progressive integration of various labor functions of primary care physicians with increasing intensity of professional activity. The solution to this problem should be under the banner of increasing the effectiveness of med...

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Aim. To assess the level of galectin-3 in blood serum of metabolic syndrome patients (MS), with heart failure (CHF).Material and methods. Totally, 43 patients investigated, with MS, and of those 37 CHF patients and 33 on-CHF, of those 17 had CHF diagnosed. Galectin-3 level in blood serum was measure...

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On October 5, 2023, on the initiative of the National Medical Research Center for Therapy and Preventive Medicine and with the support of the Russian Society for the Prevention of Noncommunicable Diseases, the III International Research and Practice Forum "Scientific and Pedagogical Schools of...

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The article is focused on clinical trials of the “obesity paradox” in patients with coronary heart disease.

The article considers the problem of monitoring the quality of training programs for internists and general practitioners, conducted during 2020-2022. The aim was to develop a methodology for monitoring the quality of programs implemented by internal medicine departments of universities in subjects...

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Among the risk factors of years of life loss, with correction for disability, the leading are arterial hypertension, smoking, high body mass index. Results of large prospective studies confirm the relation of excessive body mass with the increase of cardiovascular risk. Relative risk of cardiovascul...

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The article examines the implementation of the principle of educational space unity, ensuring the quality of education throughout the Russia. We also describe the interdependence of practical health care needs for primary care specialists capable of providing high-quality primary care and the functi...

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Aim. To assess leptin level in blood serum of patients with metabolic syndrome (MS), including comorbidity with ischemic heart disease (IHD), to reveal possible predictive value of this marker for IHD development in MS. Material and methods. Totally, 43 MS patients studied, of those 36 with IHD, and...

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