Resultados de búsqueda - Quan Cheng
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AMPs inhibit the proliferation, migration, and invasion of lung cancer via the CHRM3/PI3K/AKT and CHRM3/MAPK pathways
Publicado 2025-07-01Enlace del recursoAimsOur previous studies indicated that the overexpression of M3 muscarinic receptor (M3R/CHRM3) is related to a poor prognosis in patients with lung cancer and that Armillaria mellea polysaccharides (AMPs) can exhibit strong anticancer activity in vitro via apoptosis-related mechanisms in lung canc...
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ImmunoCheckDB: A Comprehensive Platform for Evaluating Cancer Immunotherapy Biomarkers Through Meta‐Analyses and Multiomic Profiling
Publicado 2025-06-01Enlace del recursoABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer immunotherapy, but their clinical efficacy varies significantly due to tumor heterogeneity and patient‐specific factors. Existing databases lack comprehensive integration of ICI efficacy data and fail to explore biomarkers across p...
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Relationship between sleep characteristics and aortic aneurysm/dissection: a two-sample Mendelian randomisation study
Publicado 2025-07-01Enlace del recursoObjective The causal relationship between sleep characteristics and aortic aneurysm and dissection (AAD) is little known.Methods In this two-sample Mendelian randomisation (MR) study, we selected seven sleep-related traits (sleep duration, getting up in the morning, chronotype, nap during day, insom...
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Bridging viral hepatitis and liver cancer: Emerging concepts in pathogenesis and therapeutic innovation
Publicado 2025-06-01Enlace del recursoAbstract Background Viral hepatitis, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, represent the predominant etiological factors for hepatocellular carcinoma (HCC) worldwide. HBV and HCV drive hepatocellular malignant transformation through complex molecular mechanisms...
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The effects of soil properties, cropping systems and geographic location on soil prokaryotic communities in four maize production regions across China
Publicado 2022-07-01Enlace del recursoThe diversity of prokaryotic communities in soil is shaped by both biotic and abiotic factors. However, little is known about the major factors shaping soil prokaryotic communities at a large scale in agroecosystems. To this end, we undertook a study to investigate the impact of maize production cro...
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Braking index of PSR J1846−0258: a model of magnetic inclination evolution and its gravitational-wave implication
Publicado 2025-07-01Enlace del recursoWe explain the braking index n=2.19±0.03 of PSR J1846−0258 by incorporating the time evolution of its magnetic inclination angle and dipolar magnetic field. Based on observational timing data and the age of the associated supernova remnant (tSNR≈1.77kyr), we estimate a magnetic inclination change ra...
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THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
Publicado 2024-12-01Enlace del recursoAbstract Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance. The mechanisms by which specific subsets of CAFs facilitate oxaliplatin resistance in colorectal cancer (CRC) have not been fully explored. This study found that THBS2...
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