Search Results - Qiu Zhong

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  1. 1
    Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice

    Intranasal Administration of Cold-Adapted Live-Attenuated Eurasian Avian-like H1N1 Vaccine Candidate Confers Protection Against Different-Lineage H1N1 Viruses in Mice by Qiu Zhong, Zuchen Song, Fei Meng, Yanwen Wang, Yijie Zhang, Zijian Feng, Yali Zhang, Yujia Zhai, Yan Chen, Chuanling Qiao, Hualan Chen, Huanliang Yang

    Published 2025-05-01

    Background/Objectives: Eurasian avian-like (EA) H1N1 swine influenza viruses, with their persistent evolution and zoonotic potential, seriously threaten both swine and human health. The objective was to develop an effective vaccine against these viruses. Methods: A cold-adapted, temperature-sensitiv...

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    Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice

    Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice by Yanwen Wang, Qiu Zhong, Fei Meng, Zhang Cheng, Yijie Zhang, Zuchen Song, Yali Zhang, Zijian Feng, Yujia Zhai, Yan Chen, Chuanling Qiao, Huanliang Yang

    Published 2025-07-01

    The H1N1 swine influenza viruses CQ91 and CQ445, isolated from pigs in China, exhibited distinct virulence in mice despite sharing similar genomic constellations. CQ91 demonstrated higher pathogenicity (MLD<sub>50</sub>: 5.4 log<sub>10</sub> EID<sub>50</sub>) and...

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