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    PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

    PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth por Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L. Weintraub, David J.R. Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo

    Publicado 2025-08-01

    Summary: Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. Research on the direct interactions between...

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