Search Results - Qianqian Zhang
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Silence of MEG3 intensifies lipopolysaccharide-stimulated damage of human lung cells through modulating miR-4262
Published 2019-12-01Get full textAcute lung injury (ALI) is a serious threat for health and lives worldwide. Recently, lncRNA MEG3 has been well studied to participate in lung cancer, making us speculate that it may be essential for ALI. ALI was simulated by treatment of LPS in human lung fibroblast WI-38 cells and human PMVECs. Ce...
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Changes in texture, flavor, and protein digestion of low-salt chickpea surimi composite gel: Based on Kanto cooking model and peptidomics
Published 2025-07-01Get full textPlant and animal protein complex systems are increasingly utilized in the food industry, but thermal processing effects on their quality still require investigation. Therefore, this study investigated the effect of cooking (Kanto cooking model, 85 °C, 0–12 h) on the quality of chickpea surimi compos...
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Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population
Published 2025-07-01Get full textBackgroundWe aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.MethodsA total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs),...
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Biomechanical effect of cage size in single-level anterior cervical discectomy and fusion: a finite element analysis
Published 2025-07-01Get full textAbstract Background Anterior cervical discectomy and fusion (ACDF) is a common surgical procedure for treating cervical spine diseases, but its anterior approach can lead to complications such as dysphagia and carotid artery injury due to the large incision. However, performing ACDF under a percutan...
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Discovery of a pyridophenoselenazinium-based photosensitizer with high photodynamic efficacy against breast cancer cells
Published 2023-02-01Get full textDevelopment of efficient photosensitizers with minimal side effects is highly desirable for photodynamic therapy. Reported herein is the discovery of a novel pyridophenoselenazinium-based NIR-I photosensitizer, termed PPSe , that efficiently generated both type I and II reactive oxygen species (ROS...
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Multi-Scenario Simulation of the Dynamic Relationship Between Land Use and Carbon Storage in the Urbanization Process: A Case Study of Zhengzhou, China
Published 2025-06-01Get full textRapid urbanization enhances the necessity of exploring sustainable development paths to achieve ecological and carbon storage protection. This study takes Zhengzhou, one of the national central cities in China, as a case to investigate the dynamic correlation between urbanization (UR) and carbon sto...
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Clinicopathological and prognostic value of LINC01296 in cancers: a meta-analysis
Published 2019-12-01Get full textObjective The long intergenic non-coding RNA 01296 (LINC01296) has been reported to be overexpressed in multiple tumours. However, the role of LINC01296 in clinicopathologic and prognostic value in cancers remains completely unknown. The aim of the present meta-analysis was to comprehensively elucid...
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Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation
Published 2025-08-01Get full textObjectives: This study aimed to examine the influence of matrix stiffness on osteogenic differentiation via epigenetic mechanisms in human periodontal ligament stem cells (hPDLSCs), with implications for understanding orthodontic tooth movement. Materials and Methods: hPDLSCs were cultured on substr...
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Discovery of Novel CRK12 Inhibitors for the Treatment of Human African Trypanosomiasis: An Integrated Computational and Experimental Approach
Published 2025-05-01Get full text<b>Background:</b> Human African trypanosomiasis (HAT), caused by <i>Trypanosoma brucei</i>, is a neglected tropical disease with limited treatments, highlighting the pressing need for new drugs. Cell division cycle-2-related kinase 12 (CRK12), a pivotal protein involved in t...
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Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing
Published 2025-03-01Get full textAbstract Despite the well‐documented mutation spectra of β‐thalassemia, the genetic variants and haplotypes of globin gene clusters modulating its clinical heterogeneity remain incompletely illustrated. Here, a targeted long‐read sequencing (T‐LRS) is demonstrated to capture 20 genes/loci in 1,020 β...
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