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    Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitization

    Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitization by Andreas Glässner, Michael Steffens, Amol Fatangare, Gerda Wurpts, Per Hoffmann, Philipp N. Deck, Christine Krämer, Stefani Röseler, Albert Sickmann, Markus M. Nöthen, Amir S. Yazdi, Bernhardt Sachs

    Published 2025-07-01

    Background: The detection of drug-specific activation of T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, the LTT presents with a varying sensitivity and specificity. The aim of our study was to analyse the genome wide gene exp...

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