Search Results - Pengfei Fan
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Characterization of an mRNA-Encoded Antibody Against Henipavirus
Published 2025-07-01Get full textNipah and Hendra viruses are lethal zoonotic pathogens with no approved vaccines or therapeutics. mRNA produced via in vitro transcription enables endogenous protein expression and cost reduction. Here, we systematically screened natural and artificial untranslated regions (UTRs) and identified an o...
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Morphometric characterization of Holocene mandibles expands the ecological baseline for understanding gibbon extinction dynamics
Published 2025-06-01Get full textHuman activities have driven biodiversity loss for millennia, and conservation of ‘refugee species’ that survive as remnant populations requires insights from historical baselines. However, reconstructing the past distribution and ecology of such species is challenging due to data limitations with s...
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Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Published 2025-07-01Get full textAbstract Hendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies. Here, nine rhesus‐derived monoclonal antibodies (mAbs) targeting the fusion glycoprotein (F) prefusion conformation are...
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