Search Results - P. A. Gervas
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Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region
Published 2006-09-01Get full textMultiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result of drawing immune cells into central nervous...
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The impact of ROR1, BMI-1 expression and <i>PIK3CA</i> mutation on the prognosis of luminal breast cancer
Published 2025-05-01Get full textBreast cancer (BC) remains one of the leading causes of cancer mortality among women. Luminal BC subtypes, which are characterized by the expression of hormone receptors, account for about 70 % of all breast cancer cases. However, despite sensitivity to endocrine therapy, some patients demonstrate d...
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Endogenous and exogenous risk factors affecting the incidence of breast cancer in the population of Yakutia
Published 2023-06-01Get full textThe purpose of the study: to analyze the breast cancer incidence and breast cancer risk factors for the population of the Republic of Sakha (Yakutia) in 2011-2020. Material and Methods. The incidence of breast cancer in the population of Yakutia was analyzed using the data collected from population-...
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Ethnic aspects of hereditary breast cancer
Published 2019-04-01Get full textThis study aimed to reveal the spectrum of BRca1 and BRca2 genes mutation in various ethnic groups of the Russian Federation. asystematic literature search includes data for the past 10 years and was conducted by using electronic databases of pubmed, eliBRaRY and ect.Material and methods. The review...
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Variability of the mitochondrial genome in young Yakut patients with breast cancer
Published 2024-01-01Get full textBackground. The Sakha (Yakutia) population, the indigenous population of Siberia living in Yakutia, has one of the lowest rates of breast cancer (BC) incidence worldwide. The low BC incidence among the indigenous population of Yakutia has been reported by several authors, but to date the reasons for...
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Whole exome sequencing: the search for mutations associated with hereditary breast cancer in ethnic groups of Siberia
Published 2024-11-01Get full textHereditary breast cancer (HBC) is a heterogeneous disease caused by mutations in genes characterized by ethnic specifcity. The clinical heterogeneity of this disease signifcantly complicates its diagnosis. The use of high-throughput sequencing is one of the approaches that allow the search for genes...
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Nivolumab monotherapy in metastatic colorectal cancer: current approaches to response evaluation
Published 2022-11-01Get full textAim of the study: a systematic analysis of the modern literature data on the nivolumab monotherapy efficacy in patients with metastatic colorectal cancer (mCRC). Material and methods. The review summarizes the results of clinical studies of the nivolumab efficacy in patients with mCRC between 2012 a...
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New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman
Published 2022-01-01Get full textBackground. The identification of the ethnospecific mutations associated with hereditary breast cancer remains challenging. Next generation sequencing (Ngs) technology fully enables the compilation of germline variants associated with the risk for inherited diseases. Despite the success of the Ngs,...
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PROBLEM AND PERSPECTIVE TO IMPROVE MOLECULAR TESTING TO CHOOSE APPROPRIATE TARGET THERAPY
Published 2016-02-01Get full textIn the last decade, molecularly-targeted therapy is the most intensively developing treatment modalities in oncology. The main targets for this therapy are many elements of apoptosis signaling pathways and cell cycle regulation, the damage of which is associated with a malignant growth. One of the a...
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A novel germline mutation of the <i>PALB2</i> gene in a young Yakut breast cancer woman
Published 2022-09-01Get full textBackground. Breast cancer (BC) is the most common female malignancy worldwide. Partner And Localizer of BRCA2 gene (PALB2) is directly involved in DNA damage response. Germline mutation in PALB2 has been identified in breast cancer and familial pancreatic cancer cases, accounting for approximately 1...
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