Risultati della ricerca - O. V. Krokhina
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CAPABILITIES OF ONE-STAGE BREAST REPAIR WITH A BECKER EXPANDING ENDOPROSTHESIS
Pubblicazione 2014-09-01TestoOrgan-preserving surgical interventions can be performed owing to improved drug and radiation therapy methods. When radical resec- tion is contraindicated, radical mastectomy is carried out, which is a serious psychological trauma to a woman.In this connection, plastic reparative surgery for breast...
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Pharmacogenetic testing of allelic variants of the CYP2D6 gene in hormone positive breast cancer
Pubblicazione 2017-10-01TestoTamoxifen is the drug of choice for endocrine therapy of hormone receptor- positive breast cancer in women in the reproductive period. The metabolic activity of tamoxifen is determined by the activity of the enzyme CYP2D6, encoded by the gene of the same name: under the action of the enzyme, tamox...
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Hereditary breast cancer: genetic and clinical hetergeneity, genetic testing, prophylactic surgery
Pubblicazione 2015-06-01Testo5–10 % of breast cancer cases are hereditary, 30 % of them are caused by BRCA1 and BRCA2 mutations (breast / ovarian cancer syndrome). Average cumulative risks of breast and ovarian cancer in BRCA1 mutation carriers run up to 87 % and 44 %, correspondingly. The risk for contralateral breast cancer i...
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