Search Results - O. S. Shifrin

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Aim of investigation. To study clinical features of chronic pancreatitis in patients with severe mesenteric atherosclerosis (calcification of celiac trunk).Material and methods. Overall 290 patients with chronic pancreatitis have been investigated. According to alcoholic and biliary etiology of dise...

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Aim. To review data on the efficiency and safety of using Ustekinumab in patients with Crohn’s disease.Key findings. Ustekinumab is a fully human monoclonal antibody of the IgG1k class to the p40 subunit of IL-12 and IL-23. The drug interrupts the cascade of humoral and cellular reactions leading to...

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Aim of review. Description of intestinal mucosal barrier permeability disruption causes as morbid factors in gastrointestinal tract (GIT) functional disorders.General provisions. Intestinal mucosal barrier is composed of several elements: pre-epithelial barrier, a mucosal lining of epithelium; epith...

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Aim of review. To present basic information on the short bowel syndrome (SBS) Summary. Patients with the SBS are quite rare in practice of a clinician and, as a rule, require multidisciplinary approach. Most frequently disease manifests by malabsorption signs: diarrhea, weight loss, macro - and micr...

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Aim of clinical case presentation. To discuss the consequences of erroneous management approach at suspicion for appendicular infiltrate, as well as options and difficulties of complicated Crohn’s disease treatment. Summary. Surgical treatment of fistulizing Crohn's disease with interorgan and...

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Aim. To assess the prevalence of erosive-ulcerative lesions of the gastric mucosa, as well as the frequency of Helicobacter pylori infection in patients with ulcerative colitis. Materials and methods. The study included 70 patients with ulcerative colitis. All patients, along with the standard exami...

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Aim: to demonstrate the management of a patient with somatization disorder and irritable bowel syndrome.Key points. A 41-yo female patient was admitted with complains of spastic lower abdomen pain, hard stool once every 1–2 days under laxative treatment (macrogol), bloating, anxiety, waiting for con...

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Aim of the lecture. To specify indications for the administration of the 5-aminosalicylic acid (5-АSA) in the patients with ulcerative colitis (UC) and to discuss the possibility of correlation between the body mass index, the disease activity and reasonability for the prescription of the mesalazine...

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The aim of review. To discuss modern concepts on interaction of bacterial cells with human body, and disorders of micro-and macroorganism interaction at inflammatory bowel diseases (IBD).Summary. Quantitative and qualitative changes of intestinal microflora are revealed in patients with IBD, with te...

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The aim of review. To analyse of publications on qualitative and quantitative changes in pattern of intestinal microflora in patients with irritable bowel syndrome (IBS) and options of its treatment by pre-, pro-, and symbiotic drugs.Key points. In the last years more and more data appear on changes...

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The aim of review. To discuss modern concepts on the structure and functions of intestinal microflora and its possible effect on development of certain diseases, as well as the basic methods of diagnostics of disorders of its qualitative and quantitative structure.Key points. Intestinal microflora p...

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The aim of review. To prove competency of application of probiotics and to analyze data of the original studies of efficacy of various probiotic agents in treatment of inflammatory bowel diseases (IBD).Summary. The role of microflora in pathogenesis of this group of diseases becomes more and more ob...

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Aim of investigation. To specify relation between trophological status, severity of relapse of ulcerative colitis (UC) and efficacy of 5-aminosalicylic acid (5-ASA) for achievement of clinical remission.Summary. Nutritional status plays important role for body recovery at relapse of chronic diseases...

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Aim of investigation. To estimate effect of probiotics and enterokinetic agents on severity of clinical symptoms, presence of bacterial overgrowth syndrome (BOS) and quality of life of patients with constipation variant of irritable bowel syndrome (IBS-C).Material and methods. Comparative analysis o...

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Aim of investigation. To estimate effect of probiotics on severity of clinical symptoms, presence of bacterial overgrowth syndrome (BOS) and quality of life at diarrheal variant of irritable bowel syndrome (IBS-D).Material and methods. In 47 patients with diagnosis of IBS-D, confirmed by conformity...

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The aim of the publication. By the example of clinical case to show modern algorithm of diagnostics and choice of pathogenically proved treatment for patient with continuously relapsing course of irritable bowel syndrome (IBS).Key points. Patient S., 20 years, has addressed in clinic with symptoms o...

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Aim of investigation. To study features of pancreatic involvement in patients with metabolic syndromeMaterial and methods. Overall 720 patients were investigated who have admitted to the clinic with referral diagnosis «chronic pancreatitis» (CP). Of them steatosis of pancreas (SP) was diagnosed in 4...

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Aim. This study is aimed at investigating the efficacy and safety of alimemazine (Teraligen®) therapy in patients with irritable bowel syndrome (IBS) associated with comorbid mental disorders (distress, anxiety, somatisation and depression).Materials and methods. During an open-label, non-comparativ...

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Introduction. Genetic predisposition in combination with environmental factors and the patient’s psychological and emotional state play a key role in the development of irritable bowel syndrome (IBS). Studies of association between genetic polymorphisms and IBS can help in understanding the key path...

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