Search Results - O. N. Tkacheva

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The review focuses on the use of oral anticoagulants in fragile elderly patients. The issues of prevalence and diagnosis of senile asthenia syndrome or “fragility”, as well as its effects on the risks of thrombosis, bleeding and death, are discussed. The evidence base, which is quite limited, for th...

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Recently obtained data have identified potential mechanisms linking D-endocrine system and blood pressure regulation. Vitamin D deficiency is associated with calcium metabolism disregulation, increased tonus of renin-angiotensin-aldosterone system, endothelial dysfunction, and metabolic syndrome dev...

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The article discusses stroke prevention in elderly patients with atrial fibrillation. The principles of choosing anticoagulant therapy in this group of patients are discussed. The importance of the safety profile of the selected anticoagulant is emphasized considering the high prevalence of comorbid...

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Aim. To assess the effects of moxonidine in terms of target blood pressure (BP) achievement; to identify potential additional benefits of moxonidine and its effects on bone metabolism and bone mineral density (BMD) in postmenopausal women with arterial hypertension (AH).Material and methods. The stu...

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Changes in the intestinal permeability in various pathologies are widely discussed in the scientific community. There is still no consensus on whether high intestinal permeability can lead to chronic noncommunicable diseases, but there is much evidence that increased permeability can aggravate some...

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The review article discusses  the safety issue of anticoagulant therapy in elderly patients with atrial fibrillation and high risk of bleeding.  An evidence base is presented demonstrating the high safety of rivaroxaban in patients over 80  years of age,  with a high risk of bleeding  and cardiovasc...

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The administration of oral anticoagulants in elderly patients with geriatric syndromes such as senile asthenia syndrome, falls and high risk of falls, dementia, polymorbidity, polypharmacy are discussed in the article. The evidence base for the anticoagulants taking in patients with atrial fibrillat...

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The review is focussed on the evidence base for anti-platelet therapy (APT) algorithms in women. Gender-specific features of haemostasis and thrombosis pathogenesis are emphasized. The “female” risk factors for thrombotic events include oral contraceptive use, pregnancy and post-labour period, menop...

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Of the main significantly prevalent modifiable risk factors of cardiovascular risk are carbohydrate and lipid metabolism disorders. Recent years have shown some findings of the mechanisms. The current review highlights contemporary understanding of the link of gut microbiota with carbohydrate and li...

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The importance of adipose tissue is much greater than it has been expected. Adipose tissue is a large endocrine organ, value of which is difficult to overestimate. Its work influences a lot of metabolic disorders, cardiovascular pathology. Recently, there is active research on the relation of obesit...

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The experience of the recent decade has led to ability of complex evaluation of human health, including not only external influences, genetic determinants, but to regard human body as an "environment" for billions of microbes that continuously interact with the host. Microbiota of the gut...

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The collected data on the interaction of human-as-host and their gut microbiota reveals new opportunities for further investigation and translation to practice the novel methods of the body influence in whole and on separate systems, particularly via correction of gut microbiota condition. Previous...

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The article provides a review of contemporary literature, which generalizes experimental and clinical data on the role of gut microbiota in atherosclerosis development. Gut microflora can be named a marker of the macroorganism condition, reacting on age-related, physiological, dietic, climatogeoraph...

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Arterial hypertension (AH) in pregnancy is associated with systemic endothelial damage, vasoconstriction, and blood rheology disturbances, that results in microcirculation disorders, tissue and organ ischemia. Antihypertensive therapy effects on endothelium and blood cells in hypertensive pregnant w...

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Osteoarthritis (OA) is the most wide-spread and socially significant disease of musculoskeletal system. Systemic inflammation and formation of proinflammatory cytokines underlie OA, which, in its turn, conditions keeping pain syndrome and cartilage degradation. Currently, theory of chondropenia, due...

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The review of a new data is provided related to novel aspects of moxonidine use in the patients with arterial hypertension. The main attention is paid to the problem of vascular ageing, telomere biology, insulin resistance and calcium-phosphorum homeostasis. The possible ways to influence this proce...

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Prevention of thromboembolic complications in patients with atrial fibrillation during catheter pulmonary veins isolation is discussed. This subject review is presented with special consideration to new anticoagulants.

The basis for the successful treatment of any disease is a clear understanding of its cause, the mechanisms of its development, and their relationship to symptoms. The article considers one of the links in the pathogenesis of arterial hypertension - an increase in the activity of the sympathetic ner...

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Calcium antagonist nifedipine, an antihypertensive and anti-anginal medication with vasodilating action, is widely used in cardiology practice. According to the recommendations on cardiovascular disease management in pregnancy, by the European Society of Cardiology (2003) and Society of Cardiology o...

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