Search Results - O. I. Kit

The aim of review. To analyze publications devoted to significant advances in treatment of colorectal cancer.Key points. Essential successes in colorectal cancer treatment are determined: improvement of surgical technique, performance of total mesorectumectomy and expanded lymph node dissections, ap...

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Introduction. High incidence and mortality rates of colorectal cancer indicate an urgent need for the use of new highly specific diagnostic and prognostic molecular markers. In this aspect, cancer testis antigens (CTA s) are of particular interest.The aim of the study was to analyze the relationship...

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Purpose of the study. Evaluation of expression of the epithelial-mesenchymal transition markers E-cadherin and ZEB1 in patients with stage II-IV colorectal cancer (CRC).Materials and methods. The study included operational material obtained from 299 patients aged 42–86 years (mean age 64.2±1.7 years...

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Background. Worldwide, more than 300,000 women are diagnosed with uterine cancer each year. Currently, the problem of finding highly specific molecular tumor markers for this disease remains relevant. Screening for gene expression of transcription factors responsible for controlling the differentiat...

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Aim. To identify the association of NFKB1, HIF1, VEGFA, VEGFB, BAX, BCL2 gene expression in prostate adenocarcinoma cells with biochemical recurrence of localized prostate cancer.Patients and methods. Three groups of patients were formed in the study – the main one, the comparison group and the cont...

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Over the past decades, transplantable cell lines have been an affordable model for studying the biology and effect of chemotherapeutic drugs on tumors. However, numerous studies have shown that these cell lines are not heterogeneous enough and cannot reflect the drug resistance of tumors that occurs...

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Aim of investigation. Development of adequate screening and diagnostic algorithms on colorectal cancer detection.Material and methods. The main group included 204 patients with colorectal cancer (CRC),that has been revealed at screening of 1669 patients by immunochemical fecal occult blood test (FOB...

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The aim of review. To estimate results of transanal endoscopic resection of rectal tumors and to analyze literature data devoted to this method.Key points. Experience of Rostov Scientific Research Institute of Oncology has allowed to confirm literature data and to turn out perspective approaches to...

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Venous thromboembolism (VTE) is often diagnosed in patients with pancreatic cancer, resulting in increased morbidity and mortality. Objective: to study the relationship between clinical characteristics and hemostatic disorders in patients with pancreatic cancer and determine their role in predicting...

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Objective: to study hormone balance changes caused by various options of neoadjuvant chemotherapy (CT) in patients with breast cancer (BC). Materials and methods. Data on 200 patients aged 30 to 65 years with primary BC (Stages IIB-IIIA), who had been treated at the Rostov Cancer Research Institute...

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The level of the metabolite 6-sulfatoxymelatonin (6-SOM) was studied on automedia before and after neoadjuvant systemic polyche- motherapy and neoadjuvant chemotherapy. Specific therapy was not found to result in normalization of 6-SOM levels, which may be regarded as a poor endogenous factor.

To identify new effective targets for immunotherapy of breast cancer, based on cancer-testis antigens (CTA), the associations were studied between CTA gene expression, clinical and pathological characteristics of breast cancer. Therefore, the aim of the study was to perform screening of CTAs specifi...

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Background. Epidural spinal cord compression (ESCC) is the most common neurological complication in metastatic spinal tumours.Materials and methods. The study included 87 spinal malignancy patients operated within 01.01.2014–30.09.2021. All patients had a  type of palliative decompressive and stabil...

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This review discusses the uniqueness of mitochondria providing normal cellular functions and at the same time involved in many pathological conditions, and also analyzes the scientific literature to clarify the effectiveness of mitochondrial transplantation in cancer treatment. Being important and s...

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Purpose. Obtaining extracranial diffuse tumor foci of glioblastoma in Balb/c Nude mice by implantation of mitochondria isolated from human glioblastoma.Material and methods. Human glioblastoma mitochondria were isolated using differential centrifugation in a high speed refrigerated centrifuge. Mitocho...

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Cancer is still the leading cause of death in developed countries. Oncolytic virus (OV) therapy is a promising new strategy for tumor growth inhibition. Despite the fact that the oncolytic function of some viruses was discovered in the last century, it has not been properly applied and recognized. T...

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Purpose of the study. Obtaining lung cancer tumors in Balb/c Nude mice by transplantation of mitochondria isolated from human malignant tumors.Materials and methods. Human lung cancer mitochondria were isolated using differential centrifugation on a high-speed refrigerated centrifuge. Mitochondrial...

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Pancreatic cancer (PC) is a lethal malignant tumor characterized by a rapid progression, invasiveness and resistance to radiochemotherapy. The development of biomarkers for the early diagnosis of the disease is relevant. Angiogenesis has been identified as a key factor in a number of pathological co...

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the purpose of the study was to analyze facts and mechanisms of the development of second malignancies after radiodiagnostic and radiotherapy procedures as well as after different medicamental treatments. the search for relevant articles published over the last 6 years was carried out using  medline...

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Purpose of the study. Improvement of the prognostic outcomes for the pancreatic fistula development in surgical treatment for pancreatic cancer by implementation of new diagnostic algorithms for magnetic resonance imaging (MRI) assessment of supposed pancreatic stump.Materials and methods. We perfor...

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