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    AGEs-RAGE manipulates tumor intrinsic pERK/Sp1/IL6 pathway and reprograms macrophage to promote intrahepatic cholangiocarcinoma progression

    AGEs-RAGE manipulates tumor intrinsic pERK/Sp1/IL6 pathway and reprograms macrophage to promote intrahepatic cholangiocarcinoma progression by Juan Zhang, Biyang Jing, Xiaojian Ni, Youpei Lin, Jiaomeng Pan, MaoPei Chen, Boheng Zhang, Lan Zhang, Ningling Ge, Ruyuan Deng, Xiao Wang, Guohe Song

    Published 2025-10-01

    Tumors often exhibit oxygen deprivation and enhanced glucose uptake, leading to glycolysis. Advanced glycation end products (AGEs) protein modifications induced by hyperglycemia—activate signaling pathways that promote cancer progression upon binding to its receptor (RAGE). In this study, AGEs-treat...

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