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Real-world efficacy of cabozantinib alone or in combination with ICIs in heavily pretreated hepatocellular carcinoma: potential role of AXL and MET expression by Kuan-Chang Lai, Te-Lin Hsu, Shih-Yao Lin, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang, San-Chi Chen
Published 2025-07-01Introduction and Objectives: Cabozantinib, a multi-kinase inhibitor targeting AXL and MET, is approved for second-line treatment of hepatocellular carcinoma (HCC). However, the combination of cabozantinib with immune checkpoint inhibitors (ICIs) remains controversial after the COSMIC-312 study. The...
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