Αποτελέσματα αναζήτησης - N. V. Ryazantseva

The lecture presents basic directions of molecular medicine development. Special attention is devoted to prior direction of identification of molecular and genetic markers of predisposition to chronic course of socially important viral infections, development of molecular basis for personalized ther...

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The erythrocyte distribution at the level of aortic arch is determined experimentally from structural-functional features. It is shown that there exists the mechanism of physiological separation of erythrocytes, which causes the prevalent income of younger and functionally valid forms of erythrocyte...

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Complex study of secretory and motor-evacuation functions of gastroduodenal complex, of adaptive capabilities of the organism in patients having duodenal ulcers in the follow-up period after various modifications of distal resection of stomach based upon Billroth-I was performed. It was revealed tha...

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In the article a view of investigators on the modern understanding of long-term viral persistence forming mechanisms on cellular and molecular levels has been presented. A question on the role of persistent virus in the induction of changes in cellular differentiation character, of chromosome appara...

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The review analyses information from recent literature and results of the authors’ own investigations concerning imbalance of programmed cell death in forming chronic viral infection. Molecular mechanisms of apoptosis modulation of immune cells by persistent viruses are discussed in the article.

Interferon system plays a key role in the antiviral response. Based on data from the literature, the most dangerous for the development of infectious diseases is the combination of risk alleles of several genes. This study focuses on the analysis of the combined effect of single nucleotide polymorph...

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A problem of interaction of laboratory diagnostics specialists and clinicians in diagnostic and treatment processes has been raised. The viewpoint of authors on the expediency of laboratory medicine fundamentals teaching in doctors’ faculties of medical colleges has been presented.

Fifty five Khakas people with Helicobacter pylori-associated ulcer disease and chronic gastritis were examined in order to estimate the production of IL-2, IL-4, and IL-10 interleukins in patients with chronic Helicobacter pylori persistence. The subpopulation composition of lymphocytes of periphera...

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Aim of investigation. To detect molecular-genetic features of Helicobacter pylori and polymorphism of main immunoregulatory interleukins genes at Khakases, to estimate their effect on outcomes of infection pathogen.Material and methods. Investigation was carried out at native population of Khakasia...

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The immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53...

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The review devotes to studying the role of cytokines in development of autoimmune diabetes mellitus, latent autoimmune diabetes in adults included. Therapeutic approaches to prevent the loss of endogenous insulin secretion are discussed. There is review of clinical trials of immunosuppressive agents...

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Some researchers found that the development of microvascular complications (nephropathy, retinopathy) with latent autoimmune diabetes adults (LADA) occurs much earlier than in type 1 diabetes mellitus. The research devoted to the study of the spectrum and the time of development of microangiopathy i...

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Tumor progression is accompanied by dysregulation of cell proliferation and apoptosis, which plays an essential role in breast cancer pathogenesis and cell resistance to chemotherapy. The role of protein carbonylation in molecular mechanisms of regulating MCF-7 breast cancer cell proliferation under...

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A complex research of the structural-metabolic features and the functional status of erythrocytes in peripheric blood of people with mental disorder and somatic pathology was carried out. It was revealed that when having schizophrenia, exogenous mental deficiency, neurotic disorder, Alzheimer's...

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The aim of this study was to reveal the features of association polymorphisms of interleukin-1 IL-1 and the antagonist of receptor for interleukin-1 IL-1Ra gene polymorphism in Mongoloids and Caucasoid from Khakassia with HP-associated gastroduodenal pathology (chronic gastritis and gastric ulcer)....

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Abstract. The article is considering certain features of immunopathogenesis exhibited in persistent viral infections, taking into account modern data and recently introduced immunological techniques. It has been revealed that a long-term persistence of hepatitis B and C viruses, tick-borne encephali...

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In the investigation it has been estimated the functional importance of gene interleukin 6 (IL6) polymorphism in progressing the chronic hepatitis C virus (HCV) infection. It has been determined the analysis of polymorphism –174 C/G frequency in gene IL6 promote zone at healthy donors and patients w...

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The aim of this study was to evaluate the impact of TNFα and their receptor in autoimmune diabetes. It was found the most pronounced inhibition of production of soluble forms of the receptor for TNFα in the background of an increased number of lymphocytes bearing membrane-associated receptors for TN...

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Data of modern literature and results of own investigations concerning the role of imbalance of immune-regulatory cytokines’ system in the mechanisms of forming severe eosinophilias of blood in pathologic processes of different genesisare analyzed in the article

The level of intracellular apoptosis regulators (cell death antagonists (Bcl-2) and agonists (CPP-32)), proliferation antigen Ki67 in lymphocytes of biopsy materials of the mucous coat of stomach at Helicobacter pylori-associated gastric ulcer and chronic gastritis in Khakassian aboriginal populatio...

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