Search Results - N. V. Perova

Long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFA): eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - have some important biological effects that can be used in cardiology. Long-chain omega-3 PUFA intake, in the dose of 3-4 g/d and more, decrease hypertriglyceridemia, thrombogenesi...

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Comparative dose-dependent ability of different statins to lower serum low-density lipoproteins (LDL) cholesterol was determined in three large meta-analysis. Besides, it was found that standardized decrease in LDL cholesterol levels on 1.0 or 1.8 mmol/l leads to rate reduction in ischemic heart dis...

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Reduction in total cholesterol (TCH) and low-density lipoprotein CH (LDL-CH) levels while taking food products enriched in plant stanol ethers (PSE) might be explained by inhibited intestine enterocyte CH absorption. PSE inhibit both food and biliary CH absorption. Unsaturated fatty acid-etherized s...

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Comments to the paper B.A. Ference, et al. Effect  of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease. A Mendelian Randomization Analysis (translation is published in №1 2013:90-98)

Phytosterols and phytostanols are plant analogs of cholesterol, inhibiting cholesterol (XCH) absorption by intestine epithelium and, therefore, decreasing CH blood levels. Sterols and especially stanols are absorbed in the intestine to a much lesser extent than CH, and their plasma concentrations ar...

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Introduction. The concept  of “moral agent” and its boundaries  are  not  currently  clearly defined.  Given the  connection between  moral  agency  and moral  responsibility,  it seems necessary to introduce  a clear  definition of “moral agent”, as  well as  to differentiate  the types of moral ag...

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Approaches to the total cardiovascular risk calculation based on the actual clinical recommendations are presented as well as the application of risk categories for the choice of strategy of dyslipidemia correction. The use of statins as lipid-lowering therapy in patients with acute coronary syndrom...

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The article is focused on postprandial hyperglycemia role in cardiovascular event (CVE) development. Modern views on postprandial hyperglycemia pathogenetic mechanisms, its effects on type 2 diabetes mellitus progression and CVE are presented. Postprandial hyperglycemia control with an alpha-glucosi...

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The review is focussed on the mechanisms of action, lipid-lowering activity, structural characteristics, and safety of plant sterins and stanols. Phytosterins and phytostanols inhibit intestinal cholesterol (CH) absorption, therefore decreasing plasma CH levels. The emphasis is put on prospective ep...

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Lipid metabolism issues are reviewed. Ways of cholesterol transformation are represented thoroughly; proteins regulating its transportation are described. Important place takes the role of high density lipoproteins in backward transportation of cholesterol from peripheral tissues. Possibilities of p...

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Current views on the efficacy criteria of hyperlipidaemia treatment with statins are considered. Requirements for generics of one of the widely used statin, simvastatin, are discussed. Data of several studies of Simvastol (generic simvastatin) and results of its use for hyperlipidaemia treatment in...

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Aim. To investigate potential gender differences in the association between plasma fibrinolytic activity (FLA) and atherosclerotic pathology in elderly people. Material and methods. This analysis was performed as a part of the prospective population-based cohort study “Stress, Ageing, and Health in...

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Aim. To analyze a dispersion of high density lipoproteid (HDL) particles in patients with coronary atherosclerosis and to find out whether there is a relation of HDL subfractional specifics and severity of coronary lesion. Material and methods. Totally 130 patients included (M/F 84/46) 30-80 y.o. (m...

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The authors studied effects of short-term (8 weeks) combined lipid-lowering and antihypertensive therapy effects on hemostatic parameters in metabolic syndrome (MS) patients. The treatment with fibrates and antihypertensive medications was associated with fibrinogen level reduction (for combination...

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Aim. To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particula...

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Aim. To prospectively assess dynamics, stability, and prognostic value of blood lipid profile (LP) in adolescents, for identifying early coronary heart disease prevention approaches. Material and methods. This prospective study included 347 boys and 332 girls. During 22-year follow-up, six clinical...

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The article reviews the trials on the association between increased functional activity of platelets and platelet membrane polyunsaturated fatty acids (PUFA), PUFA in serum lipoprotein phospholipids, and dyslipoproteinemia (DLP) type and severity. Platelet structural and functional disturbances, oft...

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Intravitreal use of vital dyes in combination with the action of endoillumination can induce a cyto- and phototoxic effect on posterior eye segment structures. The search for a staining agent with a maximum safety profile to retinal structures, intensively and selectively coloring vitreous body and...

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The world publications data about the impact of consumption and the fatty acids ratio in consumed fats on the development of cardiovascular diseases and acute complications due to atherothrombosis is presented. The role of some fat characteristics is discussed: hydrogenous saturation with different...

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Aim. To conduct a comparative research of a variety of angiographic scales with the aim to choose strict and useful scoring system for coronary artery lesion estimation. Material and methods. The cohort of patients is investigated with the age of 25-86 y. (n=502, 70,7% males), who at FSBI "SSRC...

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