Zoekresultaten - N. V. Marchenko

At present, there is a tendency in Russia to switch domestic manufacturers of drugs from the system of purchases of chemical products to own production of active pharmaceutical ingredients. The article reviews the current state of production of active pharmaceutical substances in the Russian Federat...

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In this research is carried out the review of the Russian pharmaceutical market and the comparative characteristic of medicines of group of inhibitors of a proton pomp. Data on production, registration and sales of this group of medicines are provided during 2007-2016.

The aim of the study. To analyze the course of COVID-19 infection in patients with primary biliary cholangitis (PBC).Materials and methods. In a single-center retrospective study, survey and analysis of medical records of 144 patients with PBC was carried out.Results. All patients (n = 144) received...

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Objective: to study the applicability of the neutrophil-to-lymphocyte ratio (NLR) for monitoring recipient status and for possible minimization of maintenance immunosuppression in the long-term period after liver transplantation (LT).Materials and methods. Blood samples of 19 recipients with satisfa...

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In this review of current publications, we look at the molecular mechanisms of tolerance of the liver and its allografts in terms of minimization and possibilities of withdrawing immunosuppressive therapy, mainly in the long-term period after liver transplantation. Information about clinical trials...

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Studies on the regenerative capabilities of tissues have shown that damaged liver can recover using hematopoietic stem cells (HSCs), which are able not only to replace cells in the target organ, but can also deliver trophic factors that support endogenous liver regeneration. There is practically no...

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PParry–Romberg syndrome, also known as progressive hemifacial atrophy, is a rare clinical entity of unknown origin with atrophy of skin and subcutaneous fat changes. A classic case of Parry–Romberg syndrome in a woman age 43 is presented. Initial facial changes appeared at the age of 20 years amid c...

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We have presented the first description of acute bilateral neuropathy of the abducens nerve associated with COVID-19 in a child.A boy aged 2 years 2 months acutely developed bilateral convergent strabismus, the next day fatigue, drowsiness, and a single vomiting not associated with food intake, were...

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Changes of apoptosis in liver cells are observed in patients with lesions of various etiologies. The aim of this study was a comparative evaluation of the expression of the antiapoptotic factor bcl-2 in liver at CHC and autoimmune liver diseases (AiLD). Immunohistochemical assessment of bcl -2 expre...

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The aim: to characterize the clinical and etiological features of facial palsy (FP) in children of different ages at the present stage and their correlation with the outcome and duration of the disease.Materials and methods: the data of 68 children with FP were obtained. The neurological examination...

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Aim. Evaluation of different methods of surgical treatment of patients with general purulent peritonitis, and the rationale for choosing the optimal method of surgery. Materials and methods. Experience of surgical treatment of patients with general purulent peritonitis which required relaparotomy is...

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This review includes information about epidemiological data, development feature, phenotypes, principles of classification, diagnosis, and prognosis for drug-induced liver injury (DILI). Actual clinical recommendations regarding management of the DILI arising in the chemotherapy of cancer discussed....

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Aim: localization of the new nomenclature of steatotic liver disease in Russian clinical practice.Key points. In 2023, international consensus decided to introduce a new nomenclature for steatotic liver disease. The article discusses the reasons for the change in nomenclature and the new terms adopt...

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Focal central nervous system damage can be a result of infectious process in brain or spinal cord, autoimmune or hypoxic-ischemic process and a relationship of these processes. Difficulties in differential diagnosis of variant pathogenic focuses in central nervous system are related with absence of...

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Purpose: to develop a logistic regression model for early differential diagnosis of viral and bacterial community-acquired pneumonia in children.  Materials and methods. A prospective study of the clinical and laboratory features of community-acquired pneumonia (CAP) was carried out in 130 children....

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SCIENTIFIC RELEVANCE. The high prevalence of fungal skin infections motivates expanding the range of sertaconazole products for external use.AIM. The study was a preclinical comparison of the safety, antifungal activity, and pharmacokinetics of Sertaverin® 2% medicated shampoo (VERTEX JSC, Russia) w...

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Background. In the last decade, the understanding of the pathogenesis of autoimmune hepatitis (AIH) has significantly deepened, based on the results of new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens have been optimized.Materials and methods. The...

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