Search Results - N. P. Lapochkina
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Combination therapy and rehabilitation in patients with breast diseases concurrent with cervical dysplasia
Published 2015-01-01Get full textThe breasts have been assessed in women with pre-invasive diseases of the cervix uteri in the presence of human papillomavirus infection. Thepaper describes a comprehensive approach to treating benign breast diseases and pre-invasive cervical ones with the multitargeted agentPromisan that is able to...
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Clinical case of combined correction of children's psychotraumatic experience and distress in the development of cancer
Published 2020-03-01Get full textThe article describes the results of applying the combined correction of the consequences of childhood traumatic experience, which served as the trigger that launched the onset of cancer distress. A patient with oncopathology (breast cancer) had signs of a sensitive, anxious-phobic personality. In t...
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Concentration of vitamin D metabolite – 25(OH)D3 as a predictor of breast cancer progression
Published 2023-01-01Get full textBackground. Prediction of breast cancer (BC) progression is important for the timely correction of patient therapy.Objective: to assess a relationship between BC progression and degree of vitamin D deficiency.Material and methods. A retrospective controlled study was performed. The results of examin...
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Chemoreactome analysis of 7-hydroxymatairesinol, 17-estradiol, phytoestrogen β-sitosterol and epigallocatechin-3-gallate
Published 2020-09-01Get full textThe results of the evaluation of 7-hydroximatairesinol (7-HMR) properties in comparison with control molecules (17-estradiol, phytoestrogen β-sytostirol, epigallocatechin-3-gallate) are presented. The results of chemoreactomic modeling allowed to formulate the molecular mechanisms of 7-HMR pharmacol...
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Pharmacokinetic analysis of drugs vitamin D for oral administration
Published 2019-10-01Get full textIn the group of healthy volunteers (women 24-53 years, n = 12) pharmacokinetic curves of levels 25(OH)D and 1,25(OH)D in the blood for two dosage forms of oil solution - the drug Vigantol (n = 6) and chewing tablets - Ultra-D (n = 6) were obtained. Each drug was taken once in a dose of 10,000 IU, th...
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Dose-dependent chemotranscriptomics analysis of the differential effects of vitamin D<sub>3</sub> on gene expression in human neuronal progenitor cells NPC and in MCF7 tumor cells
Published 2018-03-01Get full textResume. Different cell types respond differently to the effects of vitamin D3. The paper presents the results of a dose-dependent differential chemotranscriptome analysis of vitamin D3 in relation to breast tumor cells (MCF7 line) and neuron progenitor cells (NPC line). Expression of the genes invol...
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