Search Results - N. I. Pospekhova
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Clinical and morphological characteristics and prognosis of BRCA-associated breast cancer in women of the reproductive age
Published 2014-07-01Get full textDuring last years one should note an unstoppable increase of the breast cancer incidence among patients of reproductive age. A group of pa- tients of young age with the breast cancer whose disease is associated with the BRCA1/2 genes is of particular scientific interest. However, until now no single...
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Clinical, anamnestic, molecular and genetic criteria for Lynch syndrome
Published 2019-12-01Get full textLynch syndrome is the most common cancer-prone syndrome associated with a high risk of colorectal cancer (CRC), neoplasms of the upper gastrointestinal system, the urinary tract, the female reproductive system, brain tumours and others. The only known form of hereditary endometrial cancer is also di...
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Molecular biological subtypes of breast cancer in BRCA1 mutation carriers
Published 2021-01-01Get full textBackground. According to the literature, BRCA1-associated breast cancer (BC) most often belongs to the triple negative (TNBC) molecular subtype. The data on the contribution of other molecular subtypes to this group of patients differ among different studies.The study objective is to evaluate the fr...
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Prognostic significance of PD-L1 expression and evaluation of microsatellite instability status in patients with retroperitoneal leiomyosarcomas
Published 2019-11-01Get full textBackground. Leiomyosarcoma is one of the most common types of soft tissue sarcomas. Radical surgical resection with subsequent adjuvant chemotherapy remain the most effective treatment approach. Immunotherapy based on inhibition of PD-L1 (programmed death ligand 1) or its receptor PD1 (programmed de...
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Hereditary diffuse gastric cancer associated with a novel germline variant c.1596G>A in the <i>CDH1</i> gene
Published 2023-04-01Get full textGastric cancer is one of the most common malignancies worldwide. Approximately 10 % of patients with gastric cancer are characterized by accumulation of gastric cancer cases in their family. The hereditary forms of gastric cancer account for 1–3 % of all gastric cancer cases. Hereditary diffuse GC s...
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