Search Results - N. A. Malinovskaya

Aim. To evaluate the features of cerebral angiogenesis in the presence of neurospheres, free-floating clusters of neural stem and progenitor cells. Materials and Methods. Endothelial cells were optionally co-cultured with neurospheres were isolated from the hippocampus of 10-14-days-old C57Bl6 mice....

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Inherited retinal dystrophies (IRD) include a wide range of genetically and phenotypically heterogeneous diseases that lead to progressive loss of vision. With the development of gene therapy, it has become possible to treat two forms of IRD caused by biallelic mutations in the RPE65 gene: isolated...

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Relevance. Alzheimer's disease (AD) is a neurodegenerative disease, the drug therapy of which can only slow the progression of the disease, due to the variety of existing pathogenetic processes. A possible effective approach to the correction of symptoms can be the use of compounds with a compl...

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The aim was to study the molecular mechanisms of the violation of the structural and functional integrity ofthe blood-brain barrier in chronic neurodegeneration of the Alzheimer’s type associated with the development of cerebral angiopathy.Materials and methods. The transgenic model of Alzheimer’s d...

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The success of surgical treatment of glaucoma, stabilization and preservation of visual functions are fundamentally dependent on the steady normalization of the eye hydrodynamics. The problem of refractory, resistant to glaucoma treatment in children and adults, including congenital glaucoma, remain...

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The review covers the current concepts on structural and functional heterogeneity of brain astrocytes that serve for numerous (patho)physiological processes in the central nervous system. Astrocytes from various subpopulations demonstrate different sensitivity to the action of pathogenic factors, va...

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Objective: to study the mechanism that is responsible for impaired neuronal cell electroexcitability and viability, which is associated with modification of ADP-ribosyl cyclase in cerebral ischemic lesion, as well as the possibilities of pathogenet-ically correcting these disorders.Materials and met...

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The review summarizes current data on the role of insulin in the regulation of t glucose metabolism in the central nervous system at physiologic and pathologic conditions. For many years, the brain has been considered as an insulin-independent organ which utilizes glucose without insulin activity. H...

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The aim of the study was to evaluate the effect of plasma acid on the uterine tissue of laboratory animals in vitro.Materials and methods. Treatment of dimethyl sulfoxide – water solution and water for injections with a spark discharge in air resulted in a decrease in pH, which contributed to genera...

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Non-thermal plasma (NTP) in the air around the cell layer or biological tissues is considered as a generator of reactive oxygen and nitrogen species, ions, and solvated/aquated electrons. This review covers current understanding on the effects of NTP in living systems, with the focus on the role of...

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Review covers current data on molecular mechanisms of brain development in prenatal and early postnatal periods, and their alterations resulting in changes in neuroplasticity and behavioral pattern. Role of oxytocin, mechanisms of neurogenesis in normal conditions, in early-life stress and prenatal...

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