Sökresultat - Mu-Sheng Zeng
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1
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Publicerad 2025-07-01Hämta fulltextAbstract Kaposi's sarcoma‐associated herpesvirus (KSHV), a member of the human γ‐herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B‐cell malignancies. Despite its clinical significance, no effective prophylactic vaccines or speci...
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2
Neutralizing antibodies against EBV gp42 show potent in vivo protection and define novel epitopes
Publicerad 2023-12-01Hämta fulltextEpstein–Barr virus (EBV) is the first reported human oncogenic virus and infects more than 95% of the human population worldwide. EBV latent infection in B lymphocytes is essential for viral persistence. Glycoprotein gp42 is an indispensable member of the triggering complex for EBV entry into B cell...
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Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition.
Publicerad 2025-07-01Hämta fulltextHuman herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary mediator of membrane fusion during viral entry, is a key target for neutralizing antibody (nAb) and va...
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Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition
Publicerad 2025-07-01 Hämta fulltext
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OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression
Publicerad 2025-07-01Hämta fulltextSummary: Type I interferons (IFN-Is) are central coordinators of tumor-immune system interactions. Accumulating evidence suggests that persistent IFN-Is and a subset of IFN-stimulated genes (ISGs) might promote tumor development, but the regulation of mRNA translation and lipid metabolism during thi...
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