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Overexpression of <i>SEPALLATA3</i>-like Gene <i>SnMADS37</i> Generates Green Petal-Tip Flowers in <i>Solanum nigrum</i>
Published 2025-06-01Get full textThe <i>SEPALLATA3</i> (<i>SEP3</i>)-like MADS-box genes play crucial roles in determining petal identity and development in the petunia and tomato of Solanaceae. <i>Solanum nigrum</i> is a self-pollinating plant in the Solanaceae family, and produces white flowers...
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DIRAS1 Drives Oxaliplatin Resistance in Colorectal Cancer via PHB1-Mediated Mitochondrial Homeostasis
Published 2025-07-01Get full textBackground: Colorectal cancer (CRC) is a prevalent global malignancy with particularly challenging treatment outcomes in advanced stages. Oxaliplatin (OXA) is a frontline chemotherapeutic agent for CRC. However, 15% to 50% of stage III patients experience recurrence due to drug resistance. Elucidati...
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CircSPINT2 confers sensitivity to osimertinib via hsa-miR-1296-3p/RBP1 axis and inhibits NSCLC progression
Published 2025-09-01Get full textLung adenocarcinoma (LUAD) is the most common type of lung cancer. Prolonged treatment of LUAD with 1st/2nd generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) promotes the emergence of secondary EGFR T790M mutation conferring resistance to these drugs. Patients who ac...
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