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    Deoxycholic Acid and Cognitive Impairment and Decline in the Chronic Renal Insufficiency Cohort (CRIC)

    Deoxycholic Acid and Cognitive Impairment and Decline in the Chronic Renal Insufficiency Cohort (CRIC) by Parisa Mortaji, Xuan Cai, Ester Oh, Rebecca Frazier, Anand Srivastava, Michael Fischer, Ana Ricardo, Jiang He, Katherine Mills, Katherine Wolfrum, Amanda Anderson, Harold I. Feldman, Makoto Miyazaki, Michel Chonchol, Manjula Kurella Tamura, Kristen Nowak, Tamara Isakova, Anna Jovanovich, Amanda H. Anderson, PhD, MPH, Lawrence J. Appel, MD, MPH, Jing Chen, MD, MMSc, MSc, Debbie L. Cohen, MD, Laura M. Dember, MD, Alan S. Go, MD, James P. Lash, MD, Mahboob Rahman, MD, Panduranga S. Rao, MD, Vallabh O. Shah, PhD, MS, Mark L. Unruh, MD, MS

    Published 2025-07-01

    Rationale & Objective: Cognitive impairment is common in chronic kidney disease (CKD). The secondary bile acid, deoxycholic acid (DCA), is associated with cognitive impairment and Alzheimer’s dementia among older adults without CKD. Whether DCA is associated with cognitive impairment and dec...

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