Risultati della ricerca - Mei Liu
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Targeting Phosphodiesterase 4 in Gastrointestinal and Liver Diseases: From Isoform-Specific Mechanisms to Precision Therapeutics
Pubblicazione 2025-05-01TestoPhosphodiesterase 4 (PDE4) serves as a crucial regulator of cyclic adenosine monophosphate (cAMP) signaling and has been identified as a significant therapeutic target for inflammatory and metabolic disorders impacting the gastrointestinal (GI) tract and liver. Although pan-PDE4 inhibitors hold ther...
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Emodin weakens liver inflammatory injury triggered by lipopolysaccharide through elevating microRNA-145 in vitro and in vivo
Pubblicazione 2019-12-01TestoHepatitis is a severe liver disease with worldwide distribution. This study explored the anti-inflammatory influence of Emodin on LPS-triggered liver injury in vitro and in vivo. In vitro, we discovered that LPS treatment triggered L-02 cell and primary hepatocyte inflammatory injury. Emodin weakene...
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Consumer confidence and consumers' preferences for infant formulas in China
Pubblicazione 2019-08-01TestoA series of safety incidents related to domestically-produced infant formulas (DIFs) almost destroyed Chinese consumer confidence in domestic dairy products. Understanding consumer confidence and its effect on consumption behavior is important to restore consumer confidence and enhance the competiti...
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Research on a Visually Assisted Efficient Blind-Guiding System and an Autonomous Shopping Guidance Robot Arm Adapted to the Complex Environment of Farmers’ Markets
Pubblicazione 2025-06-01TestoIt is great challenge for visually impaired (VI) people to shop in narrow and crowded farmers’ markets. However, there is no research related to guiding them in farmers’ markets worldwide. This paper proposes the Radio-Frequency–Visual Tag Positioning and Automatic Detection (RFTPAD) algorithm to qu...
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Mapping subgenomic promoter of coat protein gene of Cucumber green mottle mosaic virus
Pubblicazione 2020-01-01TestoMany plant viruses utilize subgenomic RNA as gene expression strategy, therefore mapping subgenomic promoter (SGP) is extremely important for constructing viral vectors. Although Cucumber green mottle mosaic virus (CGMMV)-based virus vectors have been constructed, SGP of the coat protein (CP) has no...
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Association analysis of the sorting nexin 29 (SNX29) gene copy number variations with growth traits in Diannan small-ear (DSE) pigs
Pubblicazione 2024-12-01TestoSNX29 is a potential functional gene associated with meat production traits. Previous studies have shown that SNX29 copy number variation (CNV) could be implicated with phenotype in goats. However, in Diannan small-ear (DSE) pigs, the genetic impact of SNX29 CNV on growth traits remains unclear. The...
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Discontinuation and switching patterns of tumour necrosis factor inhibitors (TNFis) in TNFi-naive and TNFi-experienced patients with psoriatic arthritis: an observational study fro...
Pubblicazione 2019-06-01TestoObjective To examine patterns of tumour necrosis factor inhibitor (TNFi) use in TNFi-naive and TNFi-experienced patients with psoriatic arthritis (PsA) in the USA.Methods All patients aged ≥18 years with PsA enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry who initiated a TNFi...
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Unveiling the intratumor microbiome in liver cancer: Current insights and prospective applications
Pubblicazione 2025-07-01TestoThe role of the gut microbiome in the development and progression of liver cancer has long been recognized. However, the presence of microbes in tumors that were previously considered sterile has only recently been discovered. The intratumor microbiome in liver cancer likely originates from various...
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A Co-Dominant Marker BoE332 Applied to Marker-Assisted Selection of Homozygous Male-Sterile Plants in Cabbage (Brassica oleracea var. capitata L.)
Pubblicazione 2013-04-01TestoThe dominant genic male sterility (DGMS) gene CDMs399-3 derived from a spontaneous mutation in the line 79-399-3 of spring cabbage (Brassica oleracea var. capitata L.), has been successfully applied in hybrid seed production of several cabbage cultivars in China. During the development of dominant m...
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Climate Change Impact and Its Contribution Share to Paddy Rice Production in Jiangxi, China
Pubblicazione 2014-07-01TestoIn the study, an improved approach was proposed to identify the contribution shares of three group factors that are climate, technology and input, social economic factors by which the grain production is shaped. In order to calibrate the method, Jiangxi Province, one of the main paddy rice producers...
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Ca(NO3)2 canopy spraying during physiological fruit drop period has a better influence on the tree character and fruit quality of Newhall navel orange (Citrus sinensis Osbeck)
Pubblicazione 2017-07-01TestoThis study aimed to provide a theoretical basis for adopting suitable cultivation measures to tackle calcium (Ca) deficiency in citrus leaves. The Newhall navel orange (Citrus sinensis Osbeck) canopy was sprayed with 20.0 mmol L−1 of Ca(NO3)2 during physiological fruit drop period, fruit expanding p...
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Prediction of Therapeutic Response and Prognosis in Ovarian Cancer Patients With Plasma Circulating Biomarkers
Pubblicazione 2025-08-01TestoABSTRACT Background To assess whether changes in TP53 mutations and copy number alterations (CNA) in plasma circulating tumor DNA (ctDNA) can predict treatment response and prognosis in platinum‐resistant recurrent ovarian cancer (PROC) patients. Methods Fifty‐seven PROC patients were recruited. For...
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Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize
Pubblicazione 2023-10-01TestoChromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly understood. In this study, we isolated a maize...
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Dosimetric and hematological toxicity analyses of bone marrow‐sparing intensity‐modulated radiation therapy for patients with cervical cancer treated with extended‐field radiation...
Pubblicazione 2025-06-01TestoAbstract Objective This study aimed to assess the dosimetric parameters and hematological toxicity (HT) associated with bone marrow‐sparing (BMS) intensity‐modulated radiation therapy (IMRT) in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC cervical c...
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Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.
Pubblicazione 2017-04-01TestoPrior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not included individuals with an Amerindian ancestral background, such as Hispanics/Latinos, nor evaluated the full spectrum of genomic variation be...
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