Search Results - Markus Y. Mapara

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    GCK inhibition enhances iberdomide antimyeloma effects by promoting IKZF1 degradation via a CRBN-independent mechanism

    GCK inhibition enhances iberdomide antimyeloma effects by promoting IKZF1 degradation via a CRBN-independent mechanism by Shirong Li, Josefine Krüger, Guifen Liu, Huihui Ma, Michael S. Hughes, Rajshekhar Chakraborty, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch, Jing Fu

    Published 2025-08-01

    Abstract: Our recent study identifies germinal center kinase (GCK) as a novel therapeutic target in RAS-mutated multiple myeloma (MM). Inhibiting GCK downregulates critical transcriptional factors, notably IKZF1/3, BCL-6, and c-MYC proteins, leading to MM cell growth inhibition and cell death. Disti...

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