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    Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

    Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression by David P. Baird, Maximilian Reck, Ross Campbell, Marie-Helena Docherty, Piotr P. Janas, Tilly Mason, Zenuida Mortuza, Matthieu Vermeren, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Jamie P. Traynor, Patrick B. Mark, Katie J. Mylonas, Jeremy Hughes, Laura Denby, Bryan R. Conway, David A. Ferenbach

    Published 2025-07-01

    Introduction: Cellular senescence is characterized by generally irreversible cell cycle arrest and changes in secretory activity, with senescent renal epithelia proposed as drivers of kidney fibrosis. The lack of noninvasive biomarkers represents an obstacle to the design of human trials of senescen...

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