Search Results - Marcell Harhai
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POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis
Published 2025-09-01Get full textEvasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PCD triggered by excessive lipid peroxidation – remain incompletely understood. Here, we identify a previously unrecognized nucleolar-mitochondrial sign...
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An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Published 2025-08-01Get full textSummary: Mitochondrial disorders (MDs) are among the most common inborn errors of metabolism, and dysfunction in oxidative phosphorylation (OXPHOS) is a hallmark. Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging, and, to date, most lack a c...
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