Torthaí cuardaigh - M. Yu. Drokov

The article has summarized the available data about regulatory T cells, describing in-detail the stages of their studying, their development, classification, mechanisms of immunosuppression in general terms and also in the context of allogeneic hematopoietic stem cells transplantation. The effect of...

Cur síos iomlán

Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells. The article traces the evolution of the major histocompatibility complex and discusses the reasons for its format...

Cur síos iomlán

Since the middle of the last century, medical communities around the world have begun to attach great importance to the study of adherence to treatment in patients with diseases characterized by long-term and complex therapy, many complications and a potentially high risk of death. Treatment adheren...

Cur síos iomlán

Allogeneic hematopoietic stem cells transplantation is an effective method for the treatment of hematologic malignancies and other blood system diseases. Infections caused by human 6A and 6B herpes viruses are one of the leading causes of complications and mortality in hematology patients after allo...

Cur síos iomlán

Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in such cases. Monitoring chimerism makes it possi...

Cur síos iomlán

Cytomegalovirus infection is one of the critical and life-threatening infectious complications in patients after allogeneic hematopoietic stem cell transplantation. The most significant risk factors for the development of cytomegalovirus infection are cytomegalovirus serostatus of the donor and reci...

Cur síos iomlán

Graft failure is a group of complications after allogeneic hematopoietic stem cell transplantation, which occurs according to different data up to 30%. The group of complications includes primary and secondary graft failure, primary, secondary and transient poor graft function and graft rejection. D...

Cur síos iomlán

Introduction. Syngeneic hematopoietic stem cell transplantation is a type of allogeneic stem cell transplantation when the donor of stem cells is a genetically identical (monozygotic) twin of the recipient. After this type of transplantation, there is no immunological conflict as the graft versus ho...

Cur síos iomlán

A comprehensive assessment of clinical, clinico-psychopathological, neurological, neuropsychological and instrumental examinations in a single study allows for a more detailed study of cognitive impairments in patients with CSC at a long-term period (12-15 months) after the transplantation of alloge...

Cur síos iomlán

The treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual me...

Cur síos iomlán

Introduction. Natural killers are the "first line" of antitumor and antiviral protection in the early stages after аllogeneic hematopoietic stem cell transplantation. Quantitative characteristics reach normal values already in the first month after the infusion of blood stem cells to the r...

Cur síos iomlán

Background. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is being widely applied as a therapy for hematological malignancies. The long-term outcome of allo-HSCT depends directly on the ability of cytotoxic T-lymphocytes to recognize and eliminate the residual tumor. CTLA-4 is one o...

Cur síos iomlán

Background. Bloodstream infections (BSI) are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The objective of study was to analyze pre- and post-engraftment BSI.Materials and methods. From January 2018 till May 2021242 patients after first allo-HSCT were enrolled in the...

Cur síos iomlán

The graft-versus-host disease (GVHD) is among the most common complications after hematopoietic stem cell transplantation (allo-HSCT). The main tools for GVHD prevention remain calcineurin inhibitors (cyclosporin A, tacrolimus), methotrexate, mycophenolate mofetil. Upon implementation of reduced-int...

Cur síos iomlán